I have first hand experience with long term prednisone treatment - since 1988. This has also included massive pulse steroid treatments - all to no avail at the time, I'm sad to say. Anyway, I also have Temporal Lobe Epilepsy (due to Lupus) and am on Epilim. Add that drug, the steroids and the disease itself and you have big problems. If I knew 15 years ago when I was 23, how bad I would be today, I would have put my foot down about it. I have very severe osteoporosis.
Please, be very careful with going up and down with doses. I am at a stable level of 8mg/day and cannot get any lower. I put it up once and brought it back down and my rheumatologist said it's not good 'cos the body doesn't like it.
And, like everyone says, all of us are different, but it is great to share our experiences. I'm sitting here tonight with another broken bone in my foot and I curse the day I needed Prednisone! But, it did save my life...
All the best