Yes, I've been on Plaquenil for years and was on Imuran for an extended period of time, also.
Please remember that each drug affects us all differently, but I'll tell a bit of my experience. As usual, we wanted some steroid sparing agents, so the imuran was the best shot.
I had abdominal discomfort, loose bowel motions (often urgent - especially early morn). It seemed little to pay for the possibility of reducing my prednisone. However, in my case, the use of the drug did not help with my Prednisone dosage, so it was eliminated from my already enormous list of drugs!!!
I can't say, "Don't be nervous!" We all are at some time. I will be when I start Forteo in the near future. Perhaps you can comfort me, then.
I hope you feel a little better, now.
Annie Kay xx