Hi. I just stopped the methotrexate I was just too sick on it. I am sorry you may have to go through a liver biopsy. I have never had one but I have heard it is not to bad. My doctor was going to do mine at the hospital under sedation if I was going to have one done. I don't tolerate procedures well anyore. Tell your doctor how you feel and maybe he can take you off the meth and put you on something else.