Sampy: A normal ANA is below 1:40. Anything higher than that is considered positive. Angela's is considered QUITE positive!
On that note, I highly doubt that it is false positive. The chances of you having two tests showing exactly the same things WITH symptoms is highly unlikely. If you had no symptoms then maybe ONE would be a false, not two with the second one being more positive. Sheesh! I had about 20 doctors try and tell me that the Anti-dna test and 3 other Lupus related tests were false positive. My anti-dna was REALLY high positive too! This one is positive in a lot of Lupus patients and I have classic Lupus symptoms. Thank God I have a great Rheumatologist- honestly he is the best in the world! Went to England from Canada to get straightened out. Anyway!
This is the sort of info I found on Centromere pattern: Commonly this is what the centromere pattern means. anti-Centromere
ANA: Diffuse speckled nuclear
HLA type: Non-leucine residue at position 26 of HLA-DQB1 chain
Systemic scleroderma: 33%; High specificity (99%)
CREST (60% to 80%)
The Primary Raynauds would definitely explain your symptoms of the cold feet and hands.
That being said, I have found more information that I can share with you
I found quite a number of articles that relate a positive ANA (centromere) with Antiphospholipid Syndrome(APS). Have you been tested for this? I can't remember if I asked you this. I really hope that you see the Rheumatologist this month. What worries me with you is the headaches. Those can be a primary symptom of APS! So I really hope that he/she tests you for APS.
I have also found some articles that do mention thyroid being included in causing a positive ANA. I am not sure if this fully fits your "picture" though. Since you have the headaches, cold hands and feet, and the aches you describe. I think that perhaps these could be explained more by an autoimmune problem rather than Fibro. I think you know what I think of that one!!
Lots of doctors try and write patients off by saying that there problems are all related to Fibro. I disagree, and I am glad that you are seeking out help. Many people go 'Oh okay! Fibro is an answer' when really what fibro means is "muscle pain". There are people that do just have Fibro, but there are many more people that have autoimmune diseases that are being misdiagnosed. Anyway I am getting off of topic here! Here is some more info:
"A positive result on the ANA also may show up in patients with Raynaud’s disease, juvenile chronic arthritis, or antiphospholipid antibody syndrome, but a doctor needs to rely on clinical symptoms and history for diagnosis. "
Let's try and get away from the staining here, because yes that is important, but the more important thing is that you have a positive ANA.
"Scleroderma: About 60% to 90% of patients with scleroderma have a positive ANA finding. In patients who may have this condition, the subset tests can help distinguished two forms of the disease, limited versus diffuse. The diffuse form is more severe. Limited disease is most closely associated with the anticentromere pattern of ANA staining (anticentromere test), while the diffuse form is associated with autoantibodies to the anti–Scl-70. "
Do you have a positive Anti-scl-70? If you don't then you may have Lupus, Raynauds Disease, or something totally differetn going on autoimmune wise. Have you reviewed the symptoms of Lupus? Please be sure to also read the post I made here.. I also added the "alternate criteria" for the patient that is hard to diagnose.
Here is some more information regarding APS and Lupus and the centromere pattern on the ANA.
"Anti dsDNA was found in 22 patients with SLE although 46 patients with SLE were included in the series. Antibodies to Ro (4), La (2), Sm (7), RNP (4), and to the centromere (1) were also recorded -- usually in SLE patients."
So that means that you could still have Lupus! That was a study in the states that was done on patients. I will continue looking for information to put here for you, I hope that this clarifies things! I think what you need to do is sit down and look at your health history. Perhaps you can get your chart released from your doctor for a few days? Could you find your charts from when you were a child? that would be so helpful before you go to the Rheumatologist (I really hope you do go!). Anyway, I think once you put a "picture" together it will become more clear what is going on. Then- you need to write a symptom list- I suggest going from head to toe and writing everything down that is happening right now. After that, you will be ready to go! I really think that your ANA was NOT false positive. If you have autoimmune thyroid problems chances are greater that you can have more going on! Take care okay? Please let me know if I can help. Talk to you soon