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Old 06-29-2012, 08:30 AM   #1
Join Date: Jun 2012
Location: Los Angeles, CA USA
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mln5f HB User
ANA test jumped from 1:160 to 1:1280 in two weeks but no lupus symptoms.

Hi everyone,

I would love your insight on what you think is going on with's some history:

* Two bouts of bronchitis back to back in April (given two types of antibiotics both times)
* In late May, started experiencing numbness/tingling that moved around arbitrarily (face, neck, scalp, arms, legs, back, etc...for minutes at a time)
* No other physical symptoms
* Tumor/stroke/MS ruled out with MRI
* Blood tests all normal except slightly low Vit D, 20 sedimentary rate (trace), and 1:160 positive ANA
* Kidney, liver, CBC, metabolics all normal

My rheumatologist examined me and said lupus was highly unlikely due to the fact that I have no physical symptoms associated with lupus. Thought the parasthesia was due to hormone levels adjusting (had a baby last year & just weaned off breastfeeding).

He, along with another Rheum I was scheduled to see, had me do a lupus panel just to rule out lupus. His tests haven't come back yet but hers did - ANA jumped to 1:1280 but everything else was normal. I did have a cold when I took that test. Now I'm curious to see how his tests will come back - will they show the higher titer # or be lower since I was getting over my cold when I took his test.

Could a cold virus make my ANA titer number shoot up that high? What's puzzling is that everything else - physical symptoms & blood tests - are normal.

Would love your thoughts on what this could all mean....

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Old 07-07-2012, 01:09 AM   #2
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Re: ANA test jumped from 1:160 to 1:1280 in two weeks but no lupus symptoms.

If this postive ANA is new,, you may develop symptoms later on of chronic pain and fatigue, and it can attack your nerves.

Some people have positive ANA's and are healthy/normal. As long as you don't develop symptoms, it's fine. If you do, then you'll know why..

If you get colds often, start taking vitamin C every day. It will help prevent infections and keep your immune system healthier.

Old 07-10-2012, 04:36 PM   #3
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Re: ANA test jumped from 1:160 to 1:1280 in two weeks but no lupus symptoms.

Hi, Min5f. I've also read that ANA can turn positive in advance of symptoms. *BUT* it's important to know that ANA is positive in multiple diseases and conditions, not just lupus. So if yours remains high and you experience any symptoms, in your shoes I'd expect my specialists to cast a wide net, i.e., not consider lupus as the sole possibility.

I've read that ANA can test positive only because of a passing infection or virus, but I don't know to what level (sorry).

As for tingling, I think one possible cause is low Vitamin D. I used to get a footnote on my own labs, to the effect that low levels can cause "unexplained neuro-psychiatric manifestations". I had so much tingling that I suspected I had mild MS. Wrong. It turned out to be SLE, in the moderate range, but the most photosensitive subset. So I can't be in the sun at all & still get the darned tingling when my Vitamin levels fall. For the last year I've taken supplements, and they've helped.

Some *meds* can cause elevated ANA, because they induce in some people a (usually) self-limiting form of lupus called drug-induced systemic lupus erythematosus, abbreviated DILE. Various drugs have been implicated in DILE, including commonly prescribed heart & BP meds, cholesterol meds, certain antibiotics, etc. The "cure" for this form of lupus is to discontinue the drug & never take it again. In addition to elevated ANA, I think the other main DILE markers are anti-single-stranded-DNA and anti-histone. (Those are a little different than what's seen in SLE, so that's one of the factors that helps doctors differentiate between SLE & DILE.) The serious major organ problems possible in SLE are extremely rare in DILE, I think.

Have you gotten the results of your additional tests? I hope so & that they looked good & that you feel good. Let us know how you're doing when you have a minute. Sending best wishes, Vee

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