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Old 03-20-2005, 10:32 AM   #1
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Got my results. . .

Western blot from IgenX. Can I get some help interpreting?

IGG Western Bolt
18 -
22 -
23-25 -
28 +/-
30 -
31 -
34 +/-
37 -
39 +/-
41 ++
45 +/-
58 ++
66 +
73 -
83 -
93 -

IGM
18 ++
22 -
23-25 +/-
28 -
30 ++
31 +
34 -
37 -
39 +/-
41 +
45 +
58 +
66 +
73 -
83 -
93 -

I forgot -- what's the difference between IGG and IGM? Does this test show coinfections, or is there another test for that? Thanks for your help.

 
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Old 03-20-2005, 12:44 PM   #2
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Re: Got my results. . .

Hi mdguy. The Western Blot tests for Lyme disease only. The IgM shows a more recent infection and the IgG shows a longer standing one.

Below is the breakdown of the bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

Many of the bands that are specific for Lyme are positive or equivocal on your test. I would think that a Lyme doctor would find these results significant. What does the doctor recommend?

 
Old 03-20-2005, 02:09 PM   #3
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Re: Got my results. . .

I haven't been back to the doc yet. I just got the results for his office in the mail yesterday so I haven't even had a chance to talk to him yet. The letter that his office sent said that these results were not in the normal range, and to call and make another appt, but that's all it said.

Yay, more waiting. . .

 
Old 03-21-2005, 03:27 PM   #4
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Re: Got my results. . .

/rant

Man, I'm frustrated. So obviously there must be something that the doc sees in my test results to warrant another appointment (unless he just needs to make his porsche payment), but I called the doc's office today to get an appt., and I've got to wait ANOTHER 2 weeks.

I don't think I'm nearly as ill as some of you on this board, I mean I can still drag my a** to work, but it's really frustrating to know that something's wrong and not be able to do anything for 2 more freaking weeks. How is one supposed to deal with knowing something's wrong, and there's now proof that it's NOT in my head, but "sorry, 2 weeks is the soonest the doc can get you in." Arrrgh!!

/end rant

 
Old 03-21-2005, 03:43 PM   #5
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Re: Got my results. . .

Hi MDGuy,
Sorry about the wait... I know it sucks but I would say it is typical. LLMD's are so busy and there are not enough of them to go around. Hang in there. What doc are you seeing? Does MD mean you are from Maryland?

 
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