Re: Reactive on Bands 41 and 45 - Need Help
Hi Reactive, welcome to the board!
I am sorry you have been sick for so long. Although a bulls-eye rash is a definite sign of Lyme disease, only about 50% of people who have Lyme ever get a rash. Lyme disease is the second fastest growing infectious disease in the US after AIDS and the number one vector-borne illness in the US. It is in every state, including IL. Despite this, little is being done to educate the public and medical community.
No Lyme test is completely reliable and results can vary by lab. It is important to be tested by a Lyme lab such as IgeneX in Palo Alto, CA. They use more sensitive testing and list more bands on the Western Blot. Do you know which lab did your test? Below is a breakdown of the Western Blot:
9 cross-reactive for Borrellia
12 specific for Bb
20 cross-reactive for Borrellia
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients
On the Western Blot, the CDC requires a large number of bands to show for it to be considered positive yet many people who have Lyme do not have this many bands show. Lyme doctors often focus on which bands show, some are specific for Lyme.
I cannot understand when doctors test people if they are positive, they are told it is a false positive but if it is negative they are told they do not have Lyme. You have a positive ELISA and symptoms, you need to be treated. Band 41 is usually the first to show and some people who have band 45 positive have the co-infection Ehrlichiosis. It would be interesting to see what your results would be at IgeneX.
It is very important to see a knowledgeable doctor. Many doctors do not understand Lyme and treat with outdated protocols. Besides Lyme, ticks can transmit several co-infections including Babesiosis, Ehrlichiosis (HME & HGE), Bartonella, and Mycoplasma. Many people who have Lyme are co-infected, and it may affect treatment choice and progress. Babesiosis can cause heart palpitations. It is important to be tested for these by a Lyme reputable lab such as IgeneX.
I do not know of any Lyme doctors in IL. The closest one to you that I know of is in Springfield, MO. Would you like his name?
Having hypothyrodism along with Lyme disease is a double whammy. Is it regulated?
Hang in there okay? Good help is available and you are not alone.