Hi Pearl..... .....well I can't help explain the test to you......it still confuses me too....I just wanted to say....I had the 41 and 58 too....then other test nothing showed...or only the 41 showed then I had a 23 I think it was on another...had others too but don't see those test right now...pretty odd stuff uh?
I recently read an explanation of this that made sense to me. It is just speculation on the part of the person whose work I was reading, but he said this:
Since lyme can take on different forms, there are times when our bodies can't "see" the lyme. That is what the lyme intends when is changes from spirochete to L-form to cyst, it's trying to hide from the immune system and whatever attack it's under. Because of this, whenever the lyme is in the L-form or the cyst form, our bodies won't make antigens against it.
Since the Western Blot and Elisa are antigen tests, you can get a negative reading and still have lyme if your body is not identifying and fighting the lyme because it is in a form that the body doesn't recognize as an invasion.
Some Igenex tests are designed to find lyme DNA rather than our own body's antigens against lyme, for example, Igenex may show some positive or indeterminate depending on what kind of test you use. This would mean that you aren't re-infected or having lyme come and go, it means that the test (antigen versus actual lyme DNA) and/or the form of lyme that is in your body (spirochete/L/cyst) has changed.
This theory explains why some people get a rash when bitten and others don't. If the lyme isn't seen by the immune system, the rash won't appear because the rash is your body fighting lyme.
Masha: I have no words of wisdom except that the IgG and IgM stuff confuses me too. That bullseye you had last spring = Lyme infection to me. Whether it was a recent bite or a reaction of your body to an existing infection - I got no clue sweetie - sry.
I like sleeper's comments. It made sense to me to.
Also, you're talking 20 year span between 1987 and 2006. Chances are you met more than one fly or tick during that time.