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Old 04-29-2007, 10:35 PM   #1
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bigstan HB User
Lyme

Hi all. Just curious about Lyme disease testing. I had a Lyme Antibodies (EIA), blood test that turned up negative. Also shows negative for SSA, and SSB, antibody.

My question. Is that all of the tests for Lyme, or are there more detailed blood tests to diagnose this disease. I have all the symptoms.

If your out there Ticker, you seem knowledegable with this disease and I would appreciate any input.



Thanks

 
Old 04-30-2007, 04:23 AM   #2
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Beachgirl0916 HB User
Re: Lyme

Quote:
Originally Posted by bigstan View Post
Hi all. Just curious about Lyme disease testing. I had a Lyme Antibodies (EIA), blood test that turned up negative. Also shows negative for SSA, and SSB, antibody.

My question. Is that all of the tests for Lyme, or are there more detailed blood tests to diagnose this disease. I have all the symptoms.

If your out there Ticker, you seem knowledegable with this disease and I would appreciate any input.



Thanks
The EIA (ELISA) is a common and rapid test to detect Lyme disease antibodies. It is sensitive but not specific and it misses many positive cases of Lyme disease, amd often reports "false negatives."

There are MANY better tests, and they should be performed at Tick Specialty Labs. Igenex in CA, Medical Diagnotics Lab in NJ, or Stonybrook in NY...are the 3 I like the best. There is also Central FLorida research in FL.

Other tests:

Western blot test (WB)- Separates out proteins antigens of an organism you are looking for. It tells you if a person has been exposed. It is not a direct measurement of the organism. It is a measurement of whether the person has antibodies to it.

Polymerase chain reaction (PCR) -Polymerase chain reaction (PCR) testing detects the genetic material (DNA) of the Lyme disease bacteria. PCR testing may be useful for identifying a current (active) infection if you have arthritis that does not improve with antibiotic treatment. PCR testing is not done as frequently as antibody testing because it requires technical skill and expensive equipment. The PCR test is specific and sensitive. There are not as many false results with the PCR test. The PCR can be done on urine, whole blood, serum, CSF, miscellaneous (ex: Skin biopsy, breast milk, semen)

Skin culture-A skin culture evaluates a tissue sample for the bacteria that causes Lyme disease. It may take several weeks for test results to come back. For this reason, antibody testing is done more frequently than a tissue culture.

Lumbar Puncture (Spinal Tap) -Patients with neurological symptoms of Lyme disease may need to have a spinal tap in order to study “the blood of the brain,” the CSF (cerebral spinal fluid). These patients may have negative blood and urine tests and show positive results with CSF. The Western blot, LDA, and PCR can be performed on CSF.

Multiplex PCR- The standard PCR test is not always sensitive enough because of the very low numbers of organisms present. In addition, it is well known that the PCR sensitivity is reduced in the presence of inhibitors. Therefore, IGeneX has developed a nucleic acid-based Multiplex PCR diagnostic assay that simultaneously detects genomic and plasmid B.burgdorferi DNA in clinical samples.



****ALSO about 60% of Lyme patients are Co-infected with other Tick Borne Ilnesses so you need to be tested for Those too!

 
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Old 04-30-2007, 10:18 AM   #3
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Re: Lyme

Hi BigStan. I am glad you posted here. I apologize for not seeing your reply on the other post.

No Lyme test is completely reliable, and results can vary by lab. From what I understand, the ELISA or titer is the least reliable test and the one most doctors run first.

It is important to be tested by a Lyme reputable lab such as IgeneX in Palo Alto, CA. They do a test called the Western Blot. This test lists a serious of numerical "bands" with a + - or IND (indeterminate) after each number. Although the CDC requries a large number of bands to be positive for the test to be positive, many people who have Lyme do not have this many bands. Lyme doctors often look at which bands are positive--some are specific for Lyme.

When Lyme disease is a possibility, it is very important to see a knowledge- able doctor. Many doctors do not understand Lyme and treat with outdated protocols. Besides Lyme, ticks can transmit several co-infections including Babesiosis, Ehrlichiosis (HME & HGE), Bartonella, and Mycoplasma. It is estimated that 60% of people who have Lyme are co-infected. It may affect treatment choice and progress. It is important to be tested for these by a Lyme reputable lab such as IgeneX in Palo Alto, CA.

Spinal taps show Lyme is less than 5% of cases. This is an invasive test. I do not believe that Lyme doctors order this test to test for Lyme.

The only Lyme doctor I know of in MI who comes highly recommended is Dr. Michael Ledtke in Saginaw. I hope you can see someone soon and get some answers.

Keep us posted on your progress okay?

 
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