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Old 09-21-2007, 01:02 AM   #1
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bigstan HB User
41kda band

Hi all,

Just reading some good information on Allen Steere, who is largely credited with discovering Lyme disease. According to Allen Steere and the CT Ag Station, perform only a Western Blot (NEVER and ELISA), and if you have band 41 and no periodontal disease, syphilis, or obvious arthritis, you have Lyme Disease.

He went on to say:The distinction is especially important because the Lyme disease bacterium has since been discovered to regulate the expression of most of its surface proteins in a differential fashion, varying throughout infection according to stage, tissue type, temperature, and even dissolved oxygen level. Flagellin, however — the key protein in question at 41 KdA — is constitutively {always} expressed, being absolutely necessary for borrelia survival at any stage of infection. Thus, in many ways it is the most important indicator of exposure or infection, latent or active.

So to some it up, regardless of other bands on a Western Blot, if your positive with 41kda you have Lyme.

(Just great I had +++ 41kda IgeneX)

I believe all the other bands deal with co-infections.

Well time to go to work have a nice day everybody.

Last edited by bigstan; 09-21-2007 at 01:03 AM.

 
Old 09-21-2007, 07:15 AM   #2
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ktp812 HB User
Re: 41kda band

hey bigstan

That is very interesting. My sister went to see Dr. Steere and had the WB done from IgeneX. She came back with a 41++ and he told her she didn't have Lyme. He said that just about everyone has that band show up positive. Where did you read that article? I would like to read it and maybe send it to my sister who was recently diagnosed with MS. I don't believe that is what she has. Thanks- oh and mine was a +++ also.

Kim

 
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Old 09-21-2007, 02:16 PM   #3
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bigstan HB User
Re: 41kda band

Hi Ktp812, I also found it interesting espicially when the CDC indicates a person has to have two or more positive bands on the IgM, and at least five bands on the IgG. It's all too confusing for me. Anyways here is a link:

The following two reports by Allen Steere and Yale state that if a person has band 41 (or flagellin), Lyme symptoms, and they do not have severe periodontal disease or syphilis, they have Lyme borreliosis:
[url]http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=423723&blobtype=pdf[/url]

 
Old 09-21-2007, 04:43 PM   #4
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ktp812 HB User
Re: 41kda band

Thank you bigstan. I am going to print it and send it off to my sister. It is a very interesting article!

 
Old 09-21-2007, 10:29 PM   #5
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bigstan HB User
Re: 41kda band

Your welcome, Let me know what your sister has to say. I was told that I could have MS but the MD's were wrong. Always get second and third opinions.

 
Old 09-22-2007, 04:58 AM   #6
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ktp812 HB User
Re: 41kda band

I will let you know. She has been sick for almost 4 years and been the same route as all of us. She saw Dr. Steere and Dr. Donta and both said No Lyme. She has one lesion on her spine and had or has most of the Bartonella symptoms plus ton of the lyme symptoms. She finally just accepted the MS diagnosis and is now on daily injections. I wanted her to wait and see someone but she I don't think had the energy to keep going. I am hoping that by reading the article it might make her think again. Her injections are 50.00/daily and she has to take them forever. Thanks again

Kim

 
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