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Old 11-24-2007, 06:59 PM   #1
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Interpreting WB Igenex Lab results

Ok, I'm confused on my WB IGG results, for example, can someone tell me what this means?

**31 kDa ++++


I have several other bands present, but does the ++++ mean the intensity, and the ** mean the antibody is present?

thanks

Rachelle

 
Old 11-24-2007, 07:28 PM   #2
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Rodney99 HB User
Re: Interpreting WB Igenex Lab results

The double starred band (**) are the ones Igenex considers most important. The IGG is considered posistive by Igenex if 2 or more double starred bands are positve. Now the + symbol means intensity of the band. They can be +,++,+++, or ++++. If a band shows up, but is weaker in intensity than +, it is called IND or indeterminate. Hope that helps.

 
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Old 11-28-2007, 11:09 AM   #3
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Re: Interpreting WB Igenex Lab results

Hi Rachelle. What other bands do you have?

The Western Blot IgM tests for a more recent infection and the IgG a longer standing one. I believe the * stands for Lyme specific bands. Band 31 is a Lyme specific band. I believe the the number of + indicate degree of being positive, but I am not sure. You could call IgeneX to see.

 
Old 11-28-2007, 03:34 PM   #4
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Re: Interpreting WB Igenex Lab results

this is what Igenex says: IGG only
**23-25 kda ++
28 kda +
30 kda ++
**31 kda ++++
**34 kda -
**39 kda -
**41 kda IND
58 kda +
**83-93 kda -

 
Old 11-28-2007, 06:04 PM   #5
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Re: Interpreting WB Igenex Lab results

Hi Rachelle. Below is the breakdown of the Western Blot:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgG tests for a longer standing infection. IgeneX uses more sensitive testing and list more bands on the Western Blot. Bands 23-25 and 31 are Lyme specific bands and yours are positive. Band 41 is often the first to show and yours is IND. I am not a doctor, but I think your results are significant and merit treatment.

 
Old 11-29-2007, 06:10 AM   #6
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Re: Interpreting WB Igenex Lab results

thanks Ticker for all your help. Im going to take all my testing and try my friends doctor to see what he says..I will let you know..

Rachelle

 
Old 11-29-2007, 06:56 PM   #7
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Re: Interpreting WB Igenex Lab results

Good luck Rachelle. I hope the doctor is knowledgeable about Lyme.

 
Old 11-30-2007, 06:47 AM   #8
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Re: Interpreting WB Igenex Lab results

Thanks Ticker...I just found a web article from the Bay Area Lupus Foundation and it says" Both lupus and Lyme disease can produce arthritis, skin rash, cardiac & neuro involvement. Occasionally patients with high titer antibodies can have a false-positive lyme antibody titer? go figure? My ANA titer has been the highest ever since falling ill also. Im just praying for a miracle at this point..thanks for your help. WIll see what this other doc has to say..thanks again for your time...Rachelle

 
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