western blot bands question please??? - Lyme Disease Message Board

chis · 02-26-2001, 03:11 PM

Can you tell me if having bands 66kd, 45kd, 41kd and 30kd on the western blot IgG test mean anything at all for a diagnosis of Lyme disease? I know that you have to have a minimum of 5 bands to be considered positive for LYmes but don't these 4 mean anything at all. Why did these bands show positive. Positive for what???????????????

02-27-2001, 01:26 PM

Hi Chris. According to "Everything You Need To Know About Lyme Disease"

30kD = unknown, probably an outer surface protein; common in European and one California strain.

41kD = flagellin protein of all spirochetes; this is usually the first to appear afber Bb infection and is specific for all Borrelia

45kD = cross-reactive for all Borrelia

66kD = cross-reactive for all Borrelia, common in all bacteria

The CDC requires a large number of bands to be present for a positive, but many Lyme doctors consider which bands are positive and also take your history into account. I have a good list of resources on Lyme.

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[This message has been edited by moderator3 (edited 02-27-2001).]