It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Lyme Disease Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools
Old 09-14-2012, 12:19 PM   #1
Newbie
(female)
 
Join Date: Sep 2012
Location: Boston MA
Posts: 2
Kali1975 HB User
Please help interpret Lyme Test Tesults

Hello all,

I need help interpreting my Lyme results by Igenex. My PC believes I should be treated; however her knowledge of Lyme is very limited. Please recomend any specialist you know of in MA.

Igenex IGM Result - NEGATIVE
CDC/NYS Result - NEGATIVE
18 kDa ++
**23-25 kDa IND
28 kDa -
30 kDa -
**31 kDa -
**34 kDa IND
**39 kDa IND
**41 kDa ++
45 kDa +
58 kDa -
66 kDa -
**83-93 kDa IND

IGENEX IGG Result - NEGATIVE
CDC /NYS - Result - NEGATIVE
18 KdA -
**23-25 kDa -
28 kDa -
30 kDa -
**31 kDa IND
**34 kDa -
**39 kDa -
**41 kDa +
45 kDa -
58 kDa +
66 kDa -
**83-93 kDa -

Thank you all in advance.

 
Old 09-14-2012, 01:54 PM   #2
Junior Member
(female)
 
Join Date: Oct 2011
Location: IL
Posts: 33
Honeydew72 HB User
Re: Please help interpret Lyme Test Tesults

I see some positives...are you having any symptoms?

 
Sponsors Lightbulb
   
Old 09-14-2012, 06:58 PM   #3
Newbie
(female)
 
Join Date: Sep 2012
Location: Boston MA
Posts: 2
Kali1975 HB User
Re: Please help interpret Lyme Test Tesults

Honeydew, thank you for responding. The symptoms started back in June 2012 - fatigue, muscle and joint paint (mostly small joint on hands and feet), very strange joint "clicking", migrating pain for the first 3-4 days, flue like symptoms, vibration in feet (occasional). At the time I was tested by my PC's lab (Western Blot) and the only reactive band was IgM 23 KDA. Under my PC's recommendation, I started treatment with antibiotics (Clarithromycin 500mg/twice a day). Also, I decided to seek another opinion and as a result I saw an infectious disease specialist and he completely ruled out Lyme, so 3 weeks into the treatment and decided to stop the antibiotics. Three and a half months later, I do feel better but not 100%. Right now my PC is recommending another course (1 month) of antibiotics again, based on the Igenex results. I am not convinced I need them or perhaps I am not convinced I have Lyme on the first place. This has been very confusing and draining experience, as nobody has been able to give me certain answers.

 
Old 09-14-2012, 08:39 PM   #4
Junior Member
(female)
 
Join Date: Oct 2011
Location: IL
Posts: 33
Honeydew72 HB User
Re: Please help interpret Lyme Test Tesults

I don't know, I think that if you didn't have it, there would be no positives on your test but there are several and you also have symptoms that seem to like Lyme. I do think you need treatment. You could also have co infections as well but most regular doctors wont test.

I tested positive for just one band, but had symptoms..started getting bell's palsy but just a slight case. thanks goodness I caught it in time! don't waste your time with an infectious disease specialist.

oh and the (+) is a weak positive but still positive and the more (++) that show up the stronger it is! and some of those bands are specific for lyme..right now I don't remember which ones.

Last edited by Honeydew72; 09-14-2012 at 08:40 PM.

 
Old 09-14-2012, 09:19 PM   #5
Junior Member
(female)
 
Join Date: Oct 2011
Location: IL
Posts: 33
Honeydew72 HB User
Re: Please help interpret Lyme Test Tesults

band 18 highly specific for lyme...many will say that this band alone is a positive for lyme

band 41 flagellan protein of all spirochetes

band 45 cross reactive for all borrellia

band 58 unknown..possibly heat shock Bb protein

I just quickly went through a site I found but maybe take some time and look it up, and read about it. hope this helps.

I think the infectious disease doc rule it out for this:

CDC criteria for IgM : 2 of the following 3 bands have to be positive

ospc(22-25),39,41 (your 39 and 41 and IND=indeterminante I read that means there are antibodies present but just not enough to be a solid (+)

CDC criteria for IgG 5 of the following bands have to be positive 18, ospc(22-25) 28 30 39 41 45 58 66 93

IgM means more recent and current infection
IgG means previous exposure to bacteria or older infection

Igenex criteria for IgGand IgM testing using western blot
positive if 2 or more bands are positive ospc(23-25) 31 34 39 41 83-93

I hope I didn't confuse you

Last edited by Honeydew72; 09-14-2012 at 09:45 PM.

 
Old 09-15-2012, 05:20 AM   #6
Inactive
(female)
 
Join Date: Aug 2007
Location: NYC
Posts: 1,434
jenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB Userjenj770 HB User
Re: Please help interpret Lyme Test Tesults

Lyme is diagnosed primarily by symptoms. Many people with lyme test negative so I wouldn't put too much stock in this test. If you want a correct diagnosis you should see a lyme disease specialist, an LLMD. An infectious disease doc is not qualified to diagnose or treat lyme. Read the stickys at the top of this board - lyme newbies and two other information threads about testing and how to find an LLMD.

Good luck!

Jen

 
Old 10-15-2012, 09:13 PM   #7
Junior Member
(female)
 
Join Date: Oct 2012
Location: northeast,PA
Posts: 13
seniubr11 HB User
Re: Please help interpret Lyme Test Tesults

Hi, I'm new to this board, suffering with lyme almost 10 years, most likely misdiagnosed as fibromyalgia for 9 years.

Anyway, I wish I would have seen this article even a year ago, but it confirmed for me that I most likely had lyme all along, back in 2007, I only ever tested positive for band 58 I did not test pos on any other band. This article is from 2010.

I was always told band 58 is not specific to lyme but it IS specific. it's a heat shock protein to BB , how would it not be? and yet this is the only article I found that is the most reliable.


If one uses an expanded Western blot with revised requirement criteria for diagnosis, studies have demonstrated an improved sensitivity of detection and a low false-positive rate.





Revised Criteria with Western Blot
1. IGG WB: 2 specific band criteria has demonstrated improved sensitivity and maintained specificity

2. Can diagnose Lyme if any one band (IgG or IgM) of 18, 23, 28, 39 or 58 kDa or if any 2 or more of the following bands are present; 30, 45,41 and 93

3. If negative or require further confirmation, can obtain IGENEX WB (adds specific bands of 31, 34 an 83, which are typically seen in chronic disease)

4. Positive if any one band of 18, 23, 28,31,34, 39, 58 or 83

5. If positive for Borrelia on any test, consider testing for neurotoxins

6. Consider testing for co-infections (discussed below)

7. Check for coagulation defect (See Hypercoaguable State in CFS and FM)

 
Old 10-28-2012, 08:29 AM   #8
Junior Member
(female)
 
Join Date: Oct 2012
Location: Minneapolis, MN USA
Posts: 14
Lizalu HB User
Re: Please help interpret Lyme Test Tesults

Hi...I know it is so confusing, draining, and difficult when you different doctors are telling you different things. To put it simply, right!

IgeneX is great, but if the infection is hiding in your body, it may/may not show the full bands that are present in the body. I have *heard* that these bands can show up more once beginning treatment. Don't quote me there, and it's really expensive to keep re-testing so i wouldn't spend your money there.

I went to an Infectious Disease Doctor too--waste of money. He had worked at the Mayo Clinic here in MN previously before branching out to his own private practice. He ran all sorts of tests, said i didn't have lyme, and even when i had antibodies in my spinal column (yep he ordered a tap), he diagnosed me with CFS with "unusual neurological symptoms."

Never look back or listen to what IDSA-trained doctors tell you. In my opinion, their opinion is not worth my precious time!

Keep on trucking...

 
Closed Thread




Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off




Join Our Newsletter

Stay healthy through tips curated by our health experts.

Whoops,

There was a problem adding your email Try again

Thank You

Your email has been added








TOP THANKED CONTRIBUTORS



jojo (69), jenj770 (45), tess201 (31), ticker (14), Administrator (11), 6Blues (9), annalisa9397 (7), dganz (5), Katherine777 (5), lala52 (5)

Site Wide Totals

teteri66 (1180), MSJayhawk (1013), Apollo123 (909), Titchou (856), janewhite1 (823), Gabriel (763), ladybud (755), midwest1 (670), sammy64 (668), BlueSkies14 (607)



All times are GMT -7. The time now is 01:54 AM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!