Hi everyone, I am a newbie here. I have been taking Premarin 1.25 MG & Prometrium 200MG for about 2 yrs. I take the Premarin every day and the Prometrium for 10 days out of the month. I am still having periods because of the Prometrium (My Int. Med Dr. said) because it chemically makes you have a period. I have been going through "M" for six years. I am tired of this!! So, my Int. Med Dr put me on Prometrium 100 MG to take every day. Now I feel like I did before I started going through menopause. My breast hurt, I am cramping and I am irritable. She said this dosage my not make me have a period. After all that, has anyone experienced this problem? Sorry to be so long winded. It is just so great to find a site with all sorts of great info!!