I started taking Prempro at 42. I am now 61. I had my tubes tied at 28. After I quit taking birth control pills I had heavy periods for 10 days each every two weeks. I felt like I was in a constant period. I also had two operations for fibroids. I was also going to the doctor all the time for yeast infections and painful urination. I also had a lot of headaches.
Once I started on HRT (Prempro) my headaches stopped, I never have had any urinary track infections and the periods stopped completely.
The only problem I have had since starting HRT is some hair loss over 19 years of taking it.
I did try and stop about 5 years ago and immediately all the symptoms started coming back with the new symptom of hot flashes so I resumed it.
I feel that for all the negative aspects of HRT my life is good and I feel good.
I do have to say that I am lucky as I never get sick so maybe it just works for me. I would try something new, but I feel that for every new thing you try there is a downside to it.
Hope this helps someone.