I have never had depression in my life until this past year. The first time I felt it was last May when I was put on amoxicillin for an infected tooth. It caused a candida infection in my body, sinus's...everywhere... and I still have it because the med to get rid of it just made life too difficult to deal with. I first experienced depression about 2 weeks after rfinishing the amoxicillin. It came and went fast. I think I had it just 2 days. A couple of time since then, I've had the short burst of depression. Today it came on within minutes and I feel horrible. When I researched the candida, I found out that when the candida tries to get into your brain, the brain slows itself down to keep the candida out, causing depression. What I'm wondering is maybe the chemical changes in my brain from perimenopause is also having an effect and causing some depression as well? Has anyone here had depression that comes on really quickly and just stays a day or two and then goes away? Would this be hormonal as well as maybe candida? I know the brain goes through quite a transformation just before menopause and I read that the brain goes through a period that is similar to a drug withdrawal. Any insight on perimenopause and depression?