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Old 02-08-2008, 12:01 PM   #1
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Experience with Arimidex? Dosage recommendations?

Just wondering what other's experience with Arimidex was like. I just started taking 25mg every 3 days, about 10 days ago. How long should it take before I can tell if it's working? How long before I increase the dose, and to what, if it doesn't seem to be doing anything? How did it work out for you, good and bad?

The reason I'm taking this is because my E2 has tested high, and my testosterone and free t are on the lowish side of normal. I've also had many of the symptoms associated associated with high estrogen: Low libido and sexual disfunction, fatigue, brain fog, abdominal fat that won't go away even when I'm exercising and eating under 2000 calories/day (though I am not really overweight). I've tried Tribulus, DIM, DHEA, and a Vitex / Avena Sativa stack in the past few months, but none of them were completely successful. The Vitex and Avena Sativa together may have helped my sexual performance, but not the actual libido, or anything else. The Tribulus seemed to help the libido for a couple of weeks, but that faded...

I know that at some point I'll need to re-test my levels to see what the Arimidex is actually doing to them (my doctor doesn't think there's anything wrong with my levels, so I'm self-medicating). First I'm just going on how I feel on it to guage it's effectiveness. I realize if it drives it too low, that would be just as bad as high. Right now, then only thing noticable is better morning wood, which seems to be the standard test. However, there's no noticable difference the rest of the day, maybe a slight bit more energy, but it could just be a good week. Estrogen is lowest in the morning, right? Is it perhaps lowering it to a good level then, but getting too high after? Is there anything else anyone would recommend to take with this? Maybe a round of DIM again?

If you'd like to see the details of my "story" and test results, I've got them in an old post here: [url]http://www.healthboards.com/boards/showthread.php?t=497803[/url]

Thanks for your input!

 
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Old 02-09-2008, 06:04 PM   #2
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Re: Experience with Arimidex? Dosage recommendations?

I started Arimidex 3 months ago. my estradiol was 144. after 2 months it was 11.dosage 1mg daily.

 
Old 02-10-2008, 01:36 PM   #3
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Re: Experience with Arimidex? Dosage recommendations?

Wow, 1mg a day? I'd understood that dosage, while appropriate for women in fighting breast cancer, was way too high for men, and would cause a lot of negative side effects, in addition to totally wiping out estrogen. Have you had any negative side effects? Do you feel better than you did before? How long till you started noticing the benefits, if any?

Thanks!

 
Old 02-11-2008, 01:02 PM   #4
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Re: Experience with Arimidex? Dosage recommendations?

So, no one else here has taken this before? I thought there'd be more experience with this here....

 
Old 02-26-2008, 04:05 PM   #5
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Re: Experience with Arimidex? Dosage recommendations?

I was prescribed 1 mg a day for 14 days then 1 mg a day three days a week. This is the first day in this program I didn't have to take it as I just started it two weeks ago.

The nocturnal erections were more frequent for me. That is what I have noticed. The 1 mg is a lot but the 100 mg test cyp is producing a lot for me and I take HCG three times a week, + pregnenolone and DHEA, so E2 is going to need something powerful to keep it in check.

It will be seven to eight weeks before I get it tested but I am shooting for around 20 for E2.

From what I have been told, if you notice a decrease in nocturnal erections, then the dose may have to be lowered or spaced out more. Of course, the blood test for E2 is the surest way to know what the level is, and some men feel better with something in the thirties, others in the twenties.

I know I wake up three to four times a night for what seems like a couple of minutes, just long enough to check out the clock and roll over. With TRT including HCG and Arimidex, I notice two or three a night frequently so I assume the E2 level is okay. If I did wonder if the 1 mg Arimidex daily for two weeks would drive the erections away but they actually increased.

It is entirely possible to have the nocturnal erections and just not be aware of them. This happened to me when I did a sleep study and they said there were five that night that lasted from 20 to 40 minutes apiece, but I wasn't aware of any of them. Since I am aware of them now, I wonder if I don't have several more during the night?

Poodledog, I hope you are getting tested now and then since you are using Arimidex. More than is needed can drive E2 too low and cause some other problems. It is great that you are benefiting from it.

Bob

 
Old 02-26-2008, 04:37 PM   #6
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Re: Experience with Arimidex? Dosage recommendations?

Your thread is bringing out members who have not posted before.....good. Yes I think your dose is way too high but I have not taken it myself and my doc (Shippen) does not like to give it. I"m not sure his reasons but he has had some patients who have had bad reactions I think. Anyway, cut the pills into quarters or less and take them once or twice a week. Your morning wood test sounds reasonable for now if self medicating. An ideal level will be around 20 pg/ml. Under 10 is a a problem. Over 35 can be bad but the exact levels at where it creates issues varies from person to person. Keeping estradiol in check is very good to do as you age. It can cause serious prostate issues if too high.

 
Old 02-26-2008, 04:51 PM   #7
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Re: Experience with Arimidex? Dosage recommendations?

hayfarmer,

can you elaborate on the prostate issues (when estradiol is too high)? I read one of your posts about the tender nipples, etc. and now remember having this last year (during one of my battles with prostatitis). I'm now taking a zinc supplement (split a 50 mg tablet plus what's in my multivitamin) but keep a very watchful eye on my prostate issues. Actually, feel a lot of my ed issues come from the prostate issues (frequency/urgency/not voiding completely).

 
Old 03-04-2008, 08:48 AM   #8
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Re: Experience with Arimidex? Dosage recommendations?

I am a 67 year old man in extremely good condition.
I run, hike and ski. When I was about 53, I noticed a definite change in my sexual desire and my althletic performance. The drop has been steady and definite. I started Amiridex at a low level (.25mg)/day and could notice a difference within 36 hours! At first I though it was my imagination, but I have seen objective evidence. I plan on cutting back to an even smaller dose, of
.25 EOD.
I have not been on it long enough to see if my weight is affected, but I suspect it will be a bit easier to keep my weight where I want it.
I would not use Adex at a 1mg/day level as it is very powerful and expensive.
There are a lot of stuff out there that is phoney and do nothing except spend your money. Adex is the real deal, but don't overdo it.

 
Old 03-04-2008, 10:15 AM   #9
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Re: Experience with Arimidex? Dosage recommendations?

Gator,

When you (and others) say that Arimidex is very powerful, what do you mean? Is it that it could lower E2 too much too fast, it could cause too high an increase in free testosterone or something else?

The 1 mg a day for three days a week is what I was prescribed and want to go with through the next round of testing. I have observed that a lot of other guys are taking the .25 or .5 two or three days a week but I don't know if that was prescribed or not. Frankly, that was what I was expecting to get also but I have nothing but good things to say about the current dose, so far.

Other than a blood test, what do you think is a good way to be able to tell if any dose of Arimdex is working well?

Thanks.

Bob

 
Old 03-04-2008, 07:49 PM   #10
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Re: Experience with Arimidex? Dosage recommendations?

Judge,
There is some research on high estradiol as being the real culprit in prostate cancer....especially agressive prostate cancers. Not sure if it can cause BPH or not but I would not be surprised.

If you think about it, high estradiol makes sense as a cause for prostate issues. None of us have them when we are young and Testosterone is high. Why do we get them when old and testosterone is lower? Possibly because as we age estradiol is rising. For some men estradiol rises a lot and to unhealthy levels. Gator's post is a good example of this. All he did was take arrmidex to bring down estradiol (which by the way probably also caused his T to rise) and look at the change he has seen. I bet he is also less likely now to have prostate issues. I would not be surprise if 20 years from now, all men are tested for estradiol and treated for it if too high after they reach a certain age....say 50.

By the way DHT that is too high can also be bad for the prostate and BPH in particular but DHT in the normal range is good for the prostate....or so my doctor Shippen tells me.

Last edited by hayfarmer; 03-04-2008 at 07:52 PM.

 
Old 03-04-2008, 08:33 PM   #11
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Re: Experience with Arimidex? Dosage recommendations?

? for Hayfarmer.

What do you know about the possibility of an aromatase inhibitor causing a reduction in DHT? Think I read that on another board.

Bob

 
Old 03-04-2008, 09:13 PM   #12
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Re: Experience with Arimidex? Dosage recommendations?

Don't know about AI effecting DHT. I have heard that my doctor (Shippen) does not like to use arrimdex but I don't know exactly why. He tries lots of other ways to lower estradiol instead. I have read another post that Shippen has had at least one patient that arrimidex really screwed up his hormones.....whether or not DHT was involved I have no idea.

 
Old 03-05-2008, 06:55 AM   #13
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Re: Experience with Arimidex? Dosage recommendations?

Quote:
Originally Posted by 00slotiv View Post
Gator,

When you (and others) say that Arimidex is very powerful, what do you mean? Is it that it could lower E2 too much too fast, it could cause too high an increase in free testosterone or something else?

The 1 mg a day for three days a week is what I was prescribed and want to go with through the next round of testing. I have observed that a lot of other guys are taking the .25 or .5 two or three days a week but I don't know if that was prescribed or not. Frankly, that was what I was expecting to get also but I have nothing but good things to say about the current dose, so far.

Other than a blood test, what do you think is a good way to be able to tell if any dose of Arimidex is working well?

Thanks.

Bob
When I started Adex I could notice a difference within one day!
Since I have almost no extra body fat and I am in very good condition makes
me aware of changes faster than average.
Before I started taking it I studied some tests done on guys in their mid 60's.
one group that took 1mg/day, one took 1mg twice a week and one a placebo.
The group that took the higher dose did much better at first, but after 12 weeks, a little better, but not too much better.
I personally would like to see improvement over a long term and stay better for a long time.
While high levels of estrogen can make older men weak and prone to additional body fat, too little estrogen can affect your High density cholesterol and bone density.Arimidex is so powerful it can lower E too much.
That's why I would take the absolute minimum to get desired results. There are saliva tests you can find over the internet to test E and testerone for under 100 bucks. I would suggest taking one of these every 6 months of so to see where you are.
BTW , I have only been taking a very small amount od Adex for a short time and I can already see body fat go down.
I would go with the prescribed dose for now, but if you want to go long term find a minimum dosage that you like.

 
Old 03-05-2008, 03:53 PM   #14
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Re: Experience with Arimidex? Dosage recommendations?

Body fat huh? I can't really tell with me. When I started TRT I was 6-2 and 197. 14 weeks later I am still 197 although clearly more muscular and much stronger. I would think that there would be less fat but maybe only in the chest area so far.

For some reason, I was wondering if lowering E2 would help with fat loss, but my E2 has always been under 20 and only hit top of range on TRT (shots), so getting it back down probably won't change much for me, other than making it easier to avoid putting the fat on.

Bob

 
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