Has anyone found a way to lower their SHBG that has worked? My total T is around 600ng/dL (range 400-1080) but "free" T is only 73pg/mL (range (47-244). My SHBG is 55 nmol/L (range 11-80; however, I have seen some ranges at 10-50). I had all the symptoms of low T and started 200mg/wk t cyp approx three months ago. My free T did not increase since on T Cyp. My estogen was below 20 before and after TRT. My assumption is my SHBG is the problem. Does anyone else have similar SHBG levels to mine and similar T results? Since on TRT my libido increased but not much change in energy.
My SHBG was 44 ref range 9-45nmol/L (almost out of range) before treatment. Many thought the problem was with my E2 and to get tested right away...which I did.
17 ref range <59.
I been using AndrolGel and HCG with good results, total T 827 and free T 165.4 High (35.0-155 pg/mL). Not sure about SHBG, wasn't retested. Morning wood every morning..
I could knock a hole in the wall with it : ).
You may want to try HCG with your program and go from their. Also it does take a while before energy levels to get back to normal. If you still feel tired have a sleep study done...It can't hurt.
Just chiming in with my experiences with SHBG, etc. Before I started
TRT nearly a year ago my SHBG tested at 40. Seven months later it
tested at 43. But then 3 months later in May it came back as 65, UGH.
I questioned about it on this board then and the only reply I got was
that the test was probably in error. When it tested at 65, my E2 tested
at 27. They are supposed to be more in sync with each other, if one is
high so should be the other. Wish I understood the truth of the matter.
Controlling SHBG can be quite difficult. Normally it does go up and down with estrdiol but in your case that was not an issue so it does not fit. There may be some link to high SHBG and insuin resistance. Have you looked into that at all? It starts getting extremely complicated and beyond most doctors even at this point. Consider Dr. Romeo Mariano in Monterey CA.
The natural solution to lower high SHBG levels (from Life Extensions playbook) is to take Saw palmetto extract—320 mg/day, Nettle root extract—240 mg/day and Cruciferous vegetable extract (DIM or I3C) —400 mg/day. If that doesn't work, a more powerful prescriptive remedy advocated by Dr. Shippen is compounded Danazol troches 10mg to 20mg. Only a few TRT docs know about this and few compounding pharmacies have any experience with it.