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Old 07-27-2008, 06:25 AM   #1
Join Date: May 2005
Location: New York State, USA
Posts: 291
whytry HB User
Lowering E2 - DIM vs. Arimidex

I have been on Androgel for 2 months now and had a blood test on Friday. I don't have the results yet. I was tested for total T, free T and E2. I have been taking 100 mg of DIM the entire 2 months. I am thinking about the options in case my E2 is high.

If I understand it correctly, Arimidex prevents the conversion of T to E2 by inhibiting aromatase, while DIM gets rid or the E2 instead of inhibiting the conversion. If this is correct, then it seems that Arimidex is the better solution, as it will leave more T in the system.

Do I have this right and what do others think about the best solution to high E2?

Old 07-27-2008, 05:04 PM   #2
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Join Date: Mar 2006
Posts: 1,450
hayfarmer HB User
Re: Lowering E2 - DIM vs. Arimidex

You have it right. DIM helps the liver to metabolize the estradil and get it out of your system. However, arrmidex is a strong pharmaceutical that can have bad side effects at times and is hard on your liver over long term use. So, DIM would be preferred if it works. Also, conversion to estradiol is generally not as bad with gels as it is with shots so you likely do not have a problem anyway in this area.

Last edited by hayfarmer; 07-27-2008 at 05:05 PM.

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Old 07-27-2008, 07:25 PM   #3
Join Date: Mar 2008
Location: USA
Posts: 55
maverick22222 HB User
Re: Lowering E2 - DIM vs. Arimidex

Per Dr.Crisler DIM should never be taken alone as it can increase homocysteine levels. It is recommended to add TMG (Trimethylglycine) to balance out the homocysteine created by DIM.

Also DIM can be very strong and may lower E2 too much in some individuals. It is always better to start with a small dose and adjust accordingly.

Old 07-28-2008, 09:55 AM   #4
Join Date: May 2005
Location: New York State, USA
Posts: 291
whytry HB User
Re: Lowering E2 - DIM vs. Arimidex

I just found an interesting study in The Journal of Endocrinology and Metabolism, titled " Effects of Aromatase Inhibition in Eldery Men with Low or Boderline-Low Serum Testosterone Levels".

It was a 12 week study of 37 men with an average age of 67, split into 3 groups. Group 1 was given 1mg of Arimidex a day, Group 2 was given 1mg of Arimidex 2X per week and Group 3 was given a placebo. There was no TRT involved. After 12 weeks there was little change in the placebo group for any measured parameters. E2 levels decreased 35% for Group 1 and 37% for Group 2. Bioavailable T increased 109% for Group 1 and 55% for Group 2. Total T increased 67% for Group 1 and 31% for Group 2. LH increased 55% for Group 1 and 75% for Group 2. PSA increased 6% in Group 1 and 29% in Group 2, but the Group 2 increase was because of a larger increase in 2 of the 11 men in that group.

I realize that these doses of Arimidex are higher than what is normally recommended for men using TRT, but it is interesting that the T and LH levels rose so much when on Arimidex. The ratio of total T in ng/dl to E2 in pg/ml rose from 13 to 34 for Group 1 and from 15 to 31 for Group 2.

Last edited by whytry; 07-28-2008 at 11:16 AM. Reason: Group number and spelling

Old 07-28-2008, 08:57 PM   #5
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hayfarmer HB User
Re: Lowering E2 - DIM vs. Arimidex

That does not surprise me. E2 will of course lower T because it binds to the receptors in the hypothalmus meant for T. Estrogens are very similar to T and bind to the receptors. This tricks the hypothalmus into thinking T is high enough when it is not. So, lowering E2 can often increase T levels.

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