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Old 11-23-2009, 11:31 AM   #1
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Post Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

I have been on Testosterone replacement therapy for about 3 years and am experiencing scrotum/testicle shrinkage along w/reduced semen upon ejaculation that looks watery/more clear than white. I am new to this site and before posting this question read thru as many other posts on this subject as I could find.. they were helpful but left me w/even more questions! Here's some background on me:

-41 years old w/history of health problems/immune disorder
-Tested to have low testosterone by primary physician about 3 years ago and began weekly 1/2 cc testosterone cypionate injections that lasted for about 1 1/2 years.
-Grew tired of giving myself a shot so doctor switched me to Testim Gel 5mg tube applied daily.
-I do not know my original testosterone test number nor any of the other abbreviations on here (nor do I know what they stand for, even tho they sound important in here): LH, Estradiol, DIM, FSH, etc.
-My Thyroid was tested at my urging and it came back normal at the time (not sure which test tho)
-Also was put on Oxandrolone - 2 pills daily - around the same time (3+ yrs ago) to help maintain/increase weight and muscle, which has worked quite well
-Primary physician decided in September to wean me off Oxandrolone due to supposed now known problems it can cause and put me on synthetic Human Growth Hormone (HGH) daily shots. I could not tolerate the daily shots due to side effects, so am taking 1/2 dose every other day currently and my body can tolerate it w/no side effects so far. Doctor eventually wants me to try every day. I have reduced oxandrolone to 1 pill every other day. HGH helps to increase muscle by reducing fat - you would think good - but I have noticed my Face becoming awfully thin, almost to the point of looking gaunt, and am VERY concerned.
-About 3-4 months ago, started noticing that my scrotum never really 'hangs' anymore - always up close against my body. It appears to be shrinking and the testicles feel smaller but are around the size of a small walnut/oversized grape.
-My sperm has looked watered down and not white for some time, but w/in the last 3 months, it has begun looking really watery and hardly white at all.
-I can get erections and ejaculate just fine, altho sometimes in order to maintain an erection, it helps to take 1/2 pill of viagra

So, to say the least I am VERY concerned about all this. Here are my questions:

-At no time while prescribing Testosterone, Testim, HGH, or Oxandrolone did my Doctor ever mention that my scrotum/testicles could shrink; that I could stop producing sperm; or any side effects. I've now read on here that this normal?? That I will have to take Testosterone therapy forever?? Is this true???
-I also read on here that I should have had additional tests to find out what is causing my testosterone deficiency. Is this true? What are these tests? Is it too late now since I've been on Testosterone for 3+ years?
-Can I stop or reverse my scrotum/testicle shrinkage? How?
-What do these words/abbreviations I read on here regarding this subject mean: LH; FSH; DIM; Estradiol; HCG; Clomid?? I've searched on here but can't find any definitions of them;
-I read on here that I should be taking HCG & Clomid when taking Testosterone replacement therapy, but I dont know what they are, how to get them, or how often to take. Are they over the counter or prescribed? What do they do?
-Someone mentioned on here taking Tribestan and/or Striant to help. What do they do? How to get them?
-Should I go to see a specialist now instead of my primary physician? What kind? Urologist??
-Should I take a break from or go off forever the Testosterone replacement therapy?

I know this is alot of info and questions, but I wanted to be as detailed as possible so you could understand my situation without wasting your time by having to ask me questions. I thank you in advance for any information - I sincerely appreciate it!!

 
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Old 11-23-2009, 09:42 PM   #2
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Welcome to Healthboards. This is a great site and I hope you find your time here beneficial. Many here have diverse experiences, thus, can offer lots of support and guidance.

I will do my best to answer your questions.

Quote:
Originally Posted by Onelife68 View Post
So, to say the least I am VERY concerned about all this. Here are my questions:

-At no time while prescribing Testosterone, Testim, HGH, or Oxandrolone did my Doctor ever mention that my scrotum/testicles could shrink; that I could stop producing sperm; or any side effects. I've now read on here that this normal?? That I will have to take Testosterone therapy forever?? Is this true???
Yes, both are true. Normally, once you start HRT, it's for life. Very seldom do the causes for hypogonadism reverse themselves naturally.

The shrinkage is caused by the body sensing external sources of HRT and thus, shutting down it's own system. This is very normal, particularly for men who have been given large doses and/or shots.


Quote:
Originally Posted by Onelife68 View Post
-I also read on here that I should have had additional tests to find out what is causing my testosterone deficiency. Is this true? What are these tests? Is it too late now since I've been on Testosterone for 3+ years?
Hypogonadism is usually "primary" or "secondary." You can research both terms and find lots of good information.

No, it's not too late.


Quote:
Originally Posted by Onelife68 View Post
-Can I stop or reverse my scrotum/testicle shrinkage? How?
It's possible. Fertility drugs can jump start your own testicles, but you'd have to stop HRT as well.


Quote:
Originally Posted by Onelife68 View Post
-What do these words/abbreviations I read on here regarding this subject mean: LH; FSH; DIM; Estradiol; HCG; Clomid?? I've searched on here but can't find any definitions of them;
  • LH is Luteinizing hormone, a hormone produced by the anterior pituitary gland. LH acts upon the Leydig cells of the testis and is responsible for the production of testosterone, an androgen that exerts both endocrine activity and intratesticular activity on spermatogenesis.
  • FSH is Follicle-stimulating hormone, a hormone found in humans and other animals. It is synthesized and secreted by gonadotropes of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and Luteinizing hormone (LH) act synergistically in reproduction.

    Persistently high LH & FSH levels are indicative of situations where the normal restricting feedback from the gonad is absent, leading to a pituitary production of both LH and FSH. While this is typical in the menopause, it is abnormal in the reproductive years. There it may be a sign of: Premature menopause, Gonadal dysgenesis, Turner syndrome, Castration, Swyer syndrome, Polycystic Ovary Syndrome, Certain forms of CAH, and Testicular failure.

    Diminished secretion of LH & FSH can result in failure of gonadal function (hypogonadism). This condition is typically manifest in males as failure in production of normal numbers of sperm.
  • DIM promotes beneficial estrogen metabolism and healthy hormonal balance. This optimizes the ratio of estrogen metabolites that is crucial for breast, uterine, cervical, and prostate health. Women and men also use DIM as an integral part of succesful weight management programs.
  • Estradiol is a sex hormone. Estradiol is the predominant sex hormone present in females; however, it is present in males, albeit at lower levels, as well. It represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including the bones.

    The effect of estradiol (and estrogens) upon male reproduction is complex. Estradiol is produced in the Sertoli cells of the testes. There is evidence that estradiol is to prevent apoptosis of male germ cells. Several studies have noted that sperm counts have been declining in many parts of the world and it has been postulated that this may be related to estrogen exposure in the environment. Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis. Males with sex chromosome genetic conditions such as Klinefelters Syndrome will have a higher level of estradiol.
  • HCG is a glycoprotein hormone. Because hCG is produced also by some kinds of tumor, hCG is an important tumor marker, but it is not known whether this production is a contributing cause or an effect of tumorigenesis.

    In males, hCG injections are used to stimulate the leydig cells to synthesize testosterone. The intratesticular testosterone is necessary for spermatogenesis from the sertoli cells. Typical uses for hCG in men include hypogonadism and fertility treatment.

    In the world of performance enhancing drugs, hCG is increasingly used in combination with various anabolic androgenic steroid (AAS) cycles. As a result, hCG is included in some sports' illegal drug lists.

    When AAS are put into a male body, the body's natural negative-feedback loops cause the body to shut down its own production of testosterone via shutdown of the hypothalamic-pituitary-gonadal axis (HPGA). This causes testicular atrophy, among other things. hCG is commonly used during and after steroid cycles to maintain and restore testicular size as well as normal testosterone production.

    High levels of AASs that mimic the body's natural testosterone trigger, the hypothalamus, to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Without GnRH, the pituitary gland stops releasing luteinizing hormone (LH). LH normally travels from the pituitary via the blood stream to the testes, where it triggers the production and release of testosterone. Without LH, the testes shut down their production of testosterone. In males, hCG helps restore and maintain testosterone production in the testes by mimicking LH and triggering the production and release of testosterone.
  • Clomid is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, such as gynecomastia. It also restores the body's natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.[citation needed] Some users report that taking Clomid increases the amount of fluid produced during ejaculation.


Quote:
Originally Posted by Onelife68 View Post
-I read on here that I should be taking HCG & Clomid when taking Testosterone replacement therapy, but I dont know what they are, how to get them, or how often to take. Are they over the counter or prescribed? What do they do?
See above. They must be prescribed. These type of meds are very complex and not to be taken lightly. I will address later (below).


Quote:
Originally Posted by Onelife68 View Post
-Someone mentioned on here taking Tribestan and/or Striant to help. What do they do? How to get them?
Tribestan is a completely natural non-hormonal herbal (phytochemical) biostimulator derived from the plant Tribulus terrestris L., Bulgaricum, which contains predominantly saponins of furostanol type, with prevailing quantity of protodioscin (not less than 45% in Tribestan). It is a natural herbal alternative to synthetic anabolic hormones without any clinically proven toxic effects. It can be ordered OTC on line.

Striant is a prescription T or HRT med that is placed on the gum or cheek...It's a small patch that contains T and is released into the blood stream via small blood vessels in ones mouth.


Quote:
Originally Posted by Onelife68 View Post
-Should I go to see a specialist now instead of my primary physician? What kind? Urologist??
You have some excellent questions. I would arrange to go see either an ENDO or URO. ENDO's are the foremost experts in all the bodies chemicals, hormones and etc. A URO specializes in male and female reproductive development. Either would be fine, but a URO is the specialist in terms of how it all fits together. Quite honestly, the stage of HRT that you are in is probably way beyond your GP, unless of course he or she has taken a unique interest in such. GPs are fine for prescribing low doses of HRT, such as Androgel, but once you get into shots and etc., I would seek the services of a ENDO or URO.


Quote:
Originally Posted by Onelife68 View Post
-Should I take a break from or go off forever the Testosterone replacement therapy?
I can't answer that question. This is a very involved question that only your Dr can answer, depending on your entire medical situation.


Quote:
Originally Posted by Onelife68 View Post
I know this is alot of info and questions, but I wanted to be as detailed as possible so you could understand my situation without wasting your time by having to ask me questions. I thank you in advance for any information - I sincerely appreciate it!!
Hope that I have given you some basic information. Thanks for all the info up front as it did save me time in having to obtain more information. BTW, your GP should have your basic test results in your files/chart. This is critical information because if you seek out the services of a ENDO or URO, you will need this information. How often have you been tested since? You should be getting test at least yearly. Some do it every 6 months, but that's a little aggressive.

Best of luck to you.

Regards,

Ex

 
Old 11-24-2009, 01:25 PM   #3
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Thnks so much Executor for answering all my questions in so much detail. I definitely have a better understanding now of what I should be doing and have scheduled a visit w/my primary doc next week to go over things and hopefully get a referral to a Endo or Uro. I will also try to get my T lab test results, altho as I recall, that was only done once, way back before I started T treatment, and not annually afterward as you suggest.

At this point I would like to go completely off T therapy and try to stimulate the restart of my own production if possible. I don't know if that is possible, but knowing what I know now, that is my hope and goal. I am only 41 and do not want to live the rest of my life with increasingly shrinking genitals!!

I will keep you posted on the results.
Thanks Again!!

 
Old 11-24-2009, 08:15 PM   #4
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Quote:
Originally Posted by Onelife68 View Post
Thnks so much Executor for answering all my questions in so much detail. I definitely have a better understanding now of what I should be doing and have scheduled a visit w/my primary doc next week to go over things and hopefully get a referral to a Endo or Uro. I will also try to get my T lab test results, altho as I recall, that was only done once, way back before I started T treatment, and not annually afterward as you suggest.
Glad to help. I don't mean to be negative, and only trying to be honest and help....But, the lack of follow up testing is really negligent. Without some baseline to watch and measure, the Doc was simply making blindfolded decisions. It's even more troubling given the very strong meds he had prescribed. Just my .02.

Do you need a referral? You may want to think about just switching on your own. However that is up to you. I'd be thinking of how you're gonna approach him for the referral.


Quote:
Originally Posted by Onelife68 View Post
At this point I would like to go completely off T therapy and try to stimulate the restart of my own production if possible. I don't know if that is possible, but knowing what I know now, that is my hope and goal. I am only 41 and do not want to live the rest of my life with increasingly shrinking genitals!!
If this is your goal, an Endo or Uro could help you develop a plan. You should also know it's possible to be on HRT and stimulate the testes as well...With one of the meds you inquired about.

Also, if you don't mind me asking, are you married? Have kids? Even if not, the testes may be more about appearance than functionality. You can still have kids while on HRT and unless a partner is really hung up on testicles, they aren't required for a good sexual relationship. Chances are they've restricted about as far as they'll go given how long you've been on HRT. However, you can discuss this with your Doc.

Best of luck to you and i'll be curious to hear how your appointment goes.

Regards,

Ex

 
Old 11-25-2009, 10:38 AM   #5
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Thanks again for the advice. I do have my blood tested regularly for a variety of things, esp to make sure I am not experiencing side effects of meds, etc.. So I'm not saying I definitely wasn't periodically tested for my T levels. I may have been, but my doc only points out to me anything that is out of normal range and in his opinion important. It may be that he ran the tests and they were normal but I wasn't patient-savvy enough to ask...

Also, I did wonder if it was possible to stay on the Testim Gel and still stimulate my testicles to produce sperm, thereby hopefully having them regain some size?? So thx for mentioning that - which drugs would I want to use to do that? Would I have to take that drug indefinitely as well? Could I take an OTC supplement such as Tribestan in place of a prescribed drug while continuing to apply the Testim and expect my testicles to start producing sperm again??

Thanks!

 
Old 11-25-2009, 10:50 AM   #6
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Oh, Forgot to answer your last question: I would like to have kids, and what concerns me is my sperm has gradually went from thick and white to watery and almost clear. My scrotum is also now almost always drawn up close to my body (which sometimes can be uncomfortable) and I assume that is b/c it does not need to drop lower to regulate temperature for the sperm if none is there! So, besides the obvious abnormality of all this, I do wonder just how fertile my ejaculate would actually be...

 
Old 11-25-2009, 11:40 AM   #7
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Hi I just read your post. I just asked my doctor about getting testosterone therapy. I have what's called the klinefelter syndrome and that means that I was born with an extra chromosome. I'm an xxy male. I found out about this when my ex-wife and I wanted to have kids. She just could not get pregnant so I went to an infertility specialist and he did a biopsy. Unfortntly this syndrome prevents me from ever having kids. Maybe you have this syndrome? Everything that is happeng to you I already have. You should ask your doctor about this syndrome.

 
Old 11-30-2009, 11:38 PM   #8
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

UPDATE: I had the appointment with my Primary Physician today, explaining to him my concerns & the results of my research on here, and this is what I found out:

I asked for my initial lab Testosterone/etc. results done prior to starting the T therapy. However, altho my doctor's office has my records scanned into the computer system so they can easily be retrieved on a monitor while in the examination room, they only go back 3 years. My initial T test was prior to that, so it was unavailable. My Doctor is going to order my records from storage and hopefully I can obtain it that way.

My Doctor did say the following however during our discussions:

-That he usually puts patients whose T is below 500 on T therapy
-That he normally does NOT do - nor does he think he did - an initial LH or any of the other tests suggested on this site
-He has tested my T level once a year since starting the hormone replacement therapy, altho I was unable to find out those results, and I didnt think (mistakenly?) that they were that important since I would have been on T therapy and therefore they would not have provided the baseline results
-I did have an inital test prior to T treatment for my Thyroid and that came back basically normal
-My doctor visually inspected my scrotum and penis and stated he thought they looked "normal", but that I know my body better than anyone, and if Ive noticed changes (which I have!), then there must be some truth in that

I got the feeling at one point that the Doctor thought perhaps I was over-reacting, but at my urging he agreed to the following:

-Is referring me to an Endocrinologist
-Ordered a complete bloodwork test 2 days from now (since I have to fast prior) to include the following: liver-kidney function, glucose, thyroid (TSH), lipids, Free & Total T, Estradiol, DHT, DHEA, PSA, Homocysteine, LH, & SHBG

He also suggested I NOT stop the T therapy until I meet with the Endo and see what he has to say...

So, I wasnt able to find out much from this office visit, but I am hopeful that I am headed in the right direction.. If anyone has any further advice -Especially on what I should ask/request of the Endo Dr., please let me know...

Thanks Again!!

 
Old 12-01-2009, 09:00 PM   #9
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Quote:
Originally Posted by Onelife68 View Post
-He has tested my T level once a year since starting the hormone replacement therapy, altho I was unable to find out those results, and I didnt think (mistakenly?) that they were that important since I would have been on T therapy and therefore they would not have provided the baseline results
This is very good news. This affirms that initial testing was done and that follow up testing has been done yearly to confirm your levels. Unfortunately, he wasn't very good about communicating any of this to you. I don't mean to defend him per se, but HRT is very complicated and he probably felt like just telling you what to do vs explaining what to do. Docs can be bad about this type of thing.


Quote:
Originally Posted by Onelife68 View Post
-I did have an inital test prior to T treatment for my Thyroid and that came back basically normal
This is also good news. This rules out that something really out of the ordinary was going on.


Quote:
Originally Posted by Onelife68 View Post
-My doctor visually inspected my scrotum and penis and stated he thought they looked "normal", but that I know my body better than anyone, and if Ive noticed changes (which I have!), then there must be some truth in that
Sounds like his comments are relative to the general population, or in comparison to others. Yes, you would know yourself best, and if you've noticed a bit of contraction, then it's probably happened. However, a little is normal with HRT. I doubt you'll have much more. This would be a good question for the ENDO.


Quote:
Originally Posted by Onelife68 View Post
I got the feeling at one point that the Doctor thought perhaps I was over-reacting,
Unfortunately, I think some Docs can think this way. With no disrespect to him, he's not living with your issues / symptoms. It does appear, however, that he's been prudent with his course of therapy with you, based on all this new information.


Quote:
Originally Posted by Onelife68 View Post
but at my urging he agreed to the following:

-Is referring me to an Endocrinologist
This is excellent. You'll be able to discuss your issues / concerns with the foremost expert in HRT. I would list all my question out ahead of time so you don't forget anything. You may find that all is normal and that your other Doc can continue treating you....With any modifications of course that the ENDO may make.


Quote:
Originally Posted by Onelife68 View Post
-Ordered a complete bloodwork test 2 days from now (since I have to fast prior) to include the following: liver-kidney function, glucose, thyroid (TSH), lipids, Free & Total T, Estradiol, DHT, DHEA, PSA, Homocysteine, LH, & SHBG
More excellent news. This will enable you to have all your results for the ENDO. ENDOs are experts in how everything fits together.


Quote:
Originally Posted by Onelife68 View Post
He also suggested I NOT stop the T therapy until I meet with the Endo and see what he has to say...
I would strongly agree. It's best to continue on until the ENDO can examine everything, and then go from there. Your ENDO will also be able to answer any pros vs cons questions that you may have. Based on all the fact finding that goes on at that point, you can then decide what is the best course of action for you.


Quote:
Originally Posted by Onelife68 View Post
So, I wasnt able to find out much from this office visit, but I am hopeful that I am headed in the right direction.. If anyone has any further advice -Especially on what I should ask/request of the Endo Dr., please let me know...
I would strongly disagree.....Sounds as if it was a very productive visit for the many reasons / comments that I have made. You're definitely on the right track now, and I think you'll be in a very good position after your ENDO appt, to decide where to go from here. At the very least, you'll have all the facts from which to make good, educated decision! I think things will work out well for you.

Best of luck to you....All the answers your looking for are right around the corner.

Regards,

Ex

 
Old 01-10-2010, 10:48 AM   #10
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

One Life,

If the endo doesn't work out, you might be interested in seeing Dr. David Garcia in Columbus, who is a male hormone specialist. Haven't been to him myself but am planning to do so soon, hopefully.

Last edited by jkhh; 01-10-2010 at 10:49 AM. Reason: error

 
Old 01-22-2010, 06:38 AM   #11
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Executor, You seem very knowlegeable so I hope you can answer T replacement question. I have been on depo T injections for a year. When I started my red blood count was high normal at 5.89 but on my last labs it went up to 6.45 with a hematocrit of 59. It shocked me because my dosage wasn't that hi only 80 mg a week of depo T. I knew with injections it could do that and the doctor said not to do anything for 3 weeks and then start Androgel. My question is since my body is rebelling against testosterone injections will changing to a gel really approve things or just have the same problem? Will my red blood cells go down after 3 weeks of no tretment? It took 52 weeks to get that high so I'm thinking it will take a few months anyways before I should even attempt!?!? I'm thinking about not starting anything until I get my labs and see doctor after 2 months.The other one of my many questions is if I quit T replacement completely with the doctors help will my body start producing T like it used to? My T was 320 when I started one year ago. I'm a little worried because I'm married and w/o replacement it may be a sexless marriage and I'm only 57. The most important thing is life and with high numbers like I just got back that scares me. I did this to be more healthy not less and my body doesn't seem to want to accept it w/o raising my red blood count. My T was 985 when last taken 4 days after injection. That's my story and I'm looking forward to any helpful comments!!!!

 
Old 04-14-2010, 01:03 AM   #12
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

52Ken,
Just a few of my personal life experiences and tips to offer. Endocrinologists and Urologists do not start T replacement unless the T score is 300 or less according to my Endo and my Uro. Also, you should ask your doctors about donating blood every 8 weeks (as allowed by law) to reduce your red blood cells to a lower level. Blood Centers can also use a procedure to extract twice as many red blood cells per blood donation while returning the plasma part back into your body. Good Luck.

 
Old 04-14-2010, 04:10 AM   #13
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Quote:
Originally Posted by tboi2010 View Post
52Ken,
Just a few of my personal life experiences and tips to offer. Endocrinologists and Urologists do not start T replacement unless the T score is 300 or less according to my Endo and my Uro. Also, you should ask your doctors about donating blood every 8 weeks (as allowed by law) to reduce your red blood cells to a lower level. Blood Centers can also use a procedure to extract twice as many red blood cells per blood donation while returning the plasma part back into your body. Good Luck.
Thanks for your input.I have donated blood twice and it has helped. I have stopped T replacement completely. It was difficult but my body now seems to be like it was before T injections. Of course my libido is really low. Do you know how long it takes after stopping injections for the T to wean out of your body? With the half lives of Depo, I couldn't find online. Any other suggestions to improve my libido or naturaly increase my T? Thanks

 
Old 06-12-2010, 09:54 AM   #14
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

Hi Onelife,

Did you see the Endo yet?

What did they say?

 
Old 06-19-2010, 10:09 AM   #15
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Re: Testosterone Shot/Testim Gel/Shrinking Scrotum & Testicles/Reduced Semen - Help!

it's been about two months for me now. and unless there is soomething going on that i don't know about the testim has proven to be quite good for me. at first i had read all the warnings and concerns listed on the other posts and scared myself. at my last check up my t level has increase, erections are more regular/stronger, plenty of semen production, revitalized energy, upper body musculature increased, attitude better, more pep an my step, desire is up as I find myself staring at every woman who crosses my path. i realize it
s different for each individual; i am 60 and amd glad i started testim as it has made a noticible difference in all the areas i was concerned about before taking it (tired, no pep, sagging muscles in my upper arms and bad posture, weak tired boners with no ability to pop at the culmination of sex). That's all changed. And Imignt add, i've been running on the treadmill everday since i started so stamina has really improved. give it time. if you are 41 and having low t it clearly needs to be addressed. don't live in fear of it but embrace the changes it can bring about for you, especially at 41.

 
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