I've weaned up and down on zoloft dosages and stopped 'cold turkey'. I would not recommend just stopping all together!

When I increase/decrease dosages, I just get a moderate headache and pretty tired for 1-2 days. I'm not sure the amount of time you're looking at being off it completely, but for me personally, I'd rather decrease 50mg 3 times than 25mg 6 times. Just make sure you communicate with your doc. Good luck!