Curly100 - punkdizzle is exactly right! If you have all the flu-like side effects from Avonex, you will more than likely have those symptoms with Rebif. And since Rebif is a much higher dose than Avonex, it could get worse. Chemically, they are the same. Also, both these drugs can adversely affect your liver, so it is important if you are on either one to get blood tests done every three months to check your liver function. Best of luck!

Sharon Grace