(I think I am one of the big Avonex cheerleaders)
I don't know that Avonex
did make me feel better. I just know my change has been amazing since I began the injections. I can drive, I have more energy, I think clearly, my balance is better, I can walk farther, I have almost no problems with tingling or numbness. It may simply be a good remission but it has occurred as I took Avonex. I would really hate to have to quit.
Some of these changes could be psychosomatic; my neurologist thinks very highly of Avonex and assured me from the beginning I would be pleased. So you could say I went into it with positive thoughts. Another thing is I only know one other person on Avonex and he has had NO SYMPTOMS in the 5 years he has used it.
Just my opinion, but you asked!!
In reading a lot of the threads here, people say the shots make them feel better. From all I have read and the Drs have said, it doesn't fix anything just keeps you from progressing and limits the disability.
I too went into the shots with a positive attitude and I have felt great, after a very severe attack, ever since......a little over a year. Right before I take a deep breath and think of something that makes me happy, complete the shot and move on with my night! It works great 
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