| Re: Getting off Rebif
Actually, they dont build up a tolerance. In fact, I just had this exact conversation with my doctor and my pharmacist this week. They advise against switching from an Interferon A beta-1 to Betaseron. They also advise against switching from any other CRAB UNLESS IT IS WARRANTED, such as intolerance or, of course, any kind of allergic reaction. The meds themselves only improve as the level in your blood stream build up and it can take up to a year for Copaxone to reach full blood level, Rebif 6 months, and so on...
There are people who experience breakthrough symtoms, due to the progression of their disease, which is why CRABS are only approved for Remittant/ Relapsing MS, not Progressive. I myself, have Progresssive and am still on Rebif, simply becasue there is NO evidence that it cant continue to work, or slow down the progression of the disease; however, no one is promising me that I wont have relapses even though Im on it.
The drug is not to fault, the drug doesnt stop working..it either works for you, with your system or it doesnt..however, as the disease progresses, there are only so many options to look into. As Laren stated, some feel better getting off CRABS, if they had bad side effects or initally didnt tolerate it well. It took me 6 full months before I stopped having injection site reactions and flu like symtoms. Now, I can take it and forget it for another 2 days.
Tysabri is one which is so new, and so advanced, it may be the right drug of choice..it should definately be explored with your doctor.
Good luck.
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