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Old 02-21-2008, 02:26 PM   #1
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pregnancy

the MS magazine has an artical concerning "RESEARCH NOW"
finding genes ect---last paragraph "pregancy is the best treatment for Multiple Sclerosis"
wouldnt you think they would have had enough pregancies to follow up "this naturally occurring suppression":ma d:
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Old 02-21-2008, 06:49 PM   #2
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Re: pregancy

There is testing underway using the hormone that causes the suppression. The testing is limited to women as the hormone is produced by females during pregnancy. They reviewed the testing in the MSAA Motivator last year as well as Neurology Now.

 
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Old 02-22-2008, 07:01 AM   #3
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Re: pregancy

So far, they haven't been able to reproduce that hormone artificially.

Personally, I think this pregnancy connection is why the occurance of MS seems to have "exploded" among women since the use of better contraception has developed. Think about it.

 
Old 02-22-2008, 12:15 PM   #4
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Re: pregancy

Quote:
Originally Posted by Lisa_P View Post
So far, they haven't been able to reproduce that hormone artificially.

Personally, I think this pregnancy connection is why the occurance of MS seems to have "exploded" among women since the use of better contraception has developed. Think about it.
I think that the "explosion" of MS is based more on better medical equipment and diagnosis. Since the hormone that suppresses MS during pregnancy is only produced during pregnancy, I do not think that contraceptives are connected.

 
Old 02-22-2008, 02:49 PM   #5
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Re: pregancy

I agree with MS Jayhawk on this one; however I will also add that until 6 weeks ago, I was on those "pregnancy drugs' just not as high a dose as I would have been on, if I were pregnant.

Now that Im off them- I feel SOOOO much better, generally and MS wise.

Tough call - I agree that when pregnant, the body protects itself and general health is improved, MS wise- but I also know of several people who had the worst pregnancies ever with an MS dx, and most of them had horrendous relapses as soon as they delievered. Others on this board, will speak from their own experience and say that post delivery, they were absolutely fine.
It just goes to show how different everyone's MS is..and how it affects us all differently.

One of the things that I would definately have to question in the saying "pregancy is the best treatment for Multiple Sclerosis" is has the person who wrote this quote ever experienced the thrill of having a newborn, a 2 year old and a 5 year old and a MS relapse all at the same time? I think its pretty safe to say pregnancy is NOT the best treatment for MS at that point!
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Old 02-22-2008, 03:13 PM   #6
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Re: pregancy

Contraceptives are being tested to see if they help with MS and preventing relapses. Based on all the research I have seen it only points in the direction of helping solve some MS problems as opposed to causing them.

My doc says the risk of relapse after pregnancy is almost tripled. Research points in the direction of an irregulated immune system during this time period and a hormone crash. So relapse after pregnancy is a definitive risk. However, relapse during prenancy are very rare. To agree with MSnik's point - although relapses occur less often and your MS may be better the MS itself and drugs you make take for it may make the pregnancy particularly hard. So the MS is better the pregnancy is worse. Definately not a solution. Maybe they can learn enough for the hormones to get a cure - who knows.

On the bright side - if they are able to use pregnancy hormones to cure MS - will that justify me making my hubby get me ice cream at 3 am? It's worth a try!

- Shell

 
Old 02-22-2008, 03:38 PM   #7
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Re: pregancy

shel, I was part of the study for estrogen and MS for awhile, I couldnt hang....then, I was taking just the birthcontrol pill, with heavy estrogen doses...I didnt get pregnant, and was warned when I went off it, Id probably relapse badly. Its been almost 6 weeks- I feel so much better!

There have been discussions on this board about people who relapse after pregnancy, and I know people who have had horrible relapses- but there are a few here who had perfect pregnancies and didnt relapse as well...like I said, everyone's MS is different.

If the ice cream is justified......hmmm!
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N
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Old 02-23-2008, 06:35 AM   #8
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Re: pregnancy

Just my choice.... I have posted this some time ago.. I have been taking 8mg of estriol - the dosage determined to be in the body during the 3rd. trimester and the amount being used during the phase III trial (along with copaxone) for a drug called Trimesta. They believe that this is the dosage needed to cause the changes in the MS symptoms. I have been taking it daily for what will be 5 years this summer. Other than a little water retention, there has been no side effects. I have seen the results that the first studies showed.. there has been a significant reduction in lesions and my MS has not progressed. There has been no new activity in that time. Due to the estriol? I believe so, my drs. believe so. I read about the initial study and felt it was the right choice for me. I found out where to get the estriol and started using it much to my neuro's disagreement initially (again 4.5 yrs. ago before the other studies)... he was soon onboard after the MRI's started to show it was working and he read all the info.

I don't speak of it because it is still in trials but all indicators are that it is doing exactly what we have all hoped it will do. There are also hormone studies that are showing promising results for men.

It was a risky choice but I firmly believe I was lead to the study and it is working for me. I continue to pray that it will truly be this simple for everyone. The clinical trial does also include the copaxone with the Trimesta. During one of my conversations with a dr. at UCLA after the beginning of the first trial, she indicated they have to use one of the injectables with the estriol to get the funding needed to do the study. I guess so it didn't seem so off the wall that a hormone that has been used forever in other countries to treat menapause with great success could be our answer!?

Just fyi... no cravings for icecream but good excuse! Could explain my constant craving for taco bell though!

 
Old 02-23-2008, 06:55 AM   #9
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Re: pregnancy

p.s. Nikki... I am so glad to hear you are feeling better without the b/c.. I know this was a very scary and difficult decision for you. You continue to amaze me and are an amazing gift to this board.

 
Old 02-23-2008, 07:40 AM   #10
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Re: pregnancy

Hello Tuckersmom. Ive been waiting for the right time to post on this subject, but it came up, so I threw my two cents in..
I had an MRI last week and see my Neuro and MS specialist (both) this week coming.....when I get the results of the MRIs, Ill post again and talk about whether or not going off the BC changed anything...in the meantime, it seems to have helped my Triglyceride levels...again, to be discussed further after I see the doctor.

I wrote, what I wrote, because I was thinking of you- and another person who posts regulrarly who says she had normal pregnancies and deliveries.. without complications or relapses. I realize anything is possible and not everyone reacts the same to the hormonal changes...
BUt yes, overall, I feel so much better....

hugs to you...
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Last edited by MSNik; 02-23-2008 at 07:40 AM.

 
Old 02-23-2008, 12:34 PM   #11
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Re: pregnancy

You misunderstood me, guys! I didn't mean that contraceptives HELP. What I was saying is that a few generations ago women were usually having children or miscarriages...

 
Old 02-23-2008, 09:05 PM   #12
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Re: pregnancy

Nikki- can I ask how much estrogen were you taking? the reason I ask is (if I remember right!)I know you were concerned about not having the estrogen and if that is was helping keep things fairly stable with the MS... Based on what I have read Estriol, being used in the trials and what I take is very different in the way the body uses it compared to any estrogen used here in the US. At the 8mg dosage it makes your body think it is pregnant and the way it is absorbed into the body is different. I have never read anything about that with any other estrogen. Point being that given the difference, it may not have been doing anything for the MS and therefore there will be no problems arise from not using the high dose of the estrogen you were using. That would be good news from a risk of relaspe type of senario.

Although, I do wonder if not having the other estrogen in your system will affect you from an emotional/stress standpoint. I know before the MS made itself known, after the hysterectomy and I was taking premarin and would take myself off to see how I felt...it was a big bounce between crying and losing my temper very easily and then all of the usual menupause stuff would show up so I would start taking it again. As far as the birth control part, I don't know anything about how that may or may not affect how you feel.

Just random thoughts.

hugs back.
Lisa

 
Old 02-24-2008, 04:34 AM   #13
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Re: pregnancy

I had read that they couldn't get the synthetic estriol to work and that birth control pills weren't effective... But you're actually ON estriol? Something to talk to my doc about....

 
Old 02-24-2008, 04:43 AM   #14
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Re: pregnancy

Yes, I have been taking it for almost 5 years. I order it from a website. It has been used in other countries for many, many years to treat women for menapause. The risks associated with hormone replacements we have in the US appears to be far less with estriol. It can also be made at a compounding pharmacy but I am not a fan of those type of pharmacies. I have never been able to get a clear answer as to why we have not had it available to us here in the states.

As I said, my neuro. had not even heard of the study when I brought it to his attention 4.5 years ago. It is one of the things that show some great promise. I am anxious for this last trial to be done and to read the results.

 
Old 02-24-2008, 09:03 AM   #15
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Re: pregnancy

HI Lisa. I dont remember how much estriol I was on truthfully....however, the idea of how much estrogen is in the body is important. I was just given a script by my GYN for bloodwork to find out where I am now, on the menopausal scale- now that the extra estrogen that I was taking should be out of my system. In fact, he told me to wait 3-4 more weeks until I have the blood drawn, just to make sure all the b/c is out of my system. I am having four different tests done in order to better evaluate if I need any type of supplemets and exactly how much estrogen is being produced in my body. I didnt have a total hysterectomy, but I did lose an ovary- and with coming off the b/c, this should be telling.....

hugs
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