How many of you with diagnosed MS have shown a high ANA titre? I know that this is a marker for possible autoimmune activity but that is about as much info as I have been able to learn at this stage.
I haven't been diagnosed with MS, but a positive ANA + titer would show various autoimmune diseases, especially Lupus. ANAs can be found in patients with infections, cancer, lung diseases, gastrointestinal diseases, hormonal diseases, blood diseases, skin diseases, and in elderly people or people with a family history of rheumatic disease.
Hi April. An ANA Titre is Antinuclear Antibodies, which is a blood test, measured in Titres..
It measures the amount of antibodies in your blood....the word titre measures how far the antibodies can be diluted before they can no longer be picked up in a blood test..
ANA tests can measure things like Lupus, Reumetoid Arthritis, Raynaud's syndrome, Addidson's Disease, Hepatitis, Hashimoto's Thyroiditis and assorted other diseaes. It can NOT find out if MS is present, however being that it definately can find out that an Auto-Immune Disease is present, it helps doctors to figure out what it ISNT. As we all know, MS is only dx, if everything else is ruled out....but since it is an auto-immune disease, presence of elevated ANA is usually seen...
hope this helps?
A person with MS would always have elevated antiibodies...whether or not they would flareup during an excaberation, Im not entirely sure. It wouldnt make sense that they would get higher, because its not like a flu- and they arent like white blood cells, they dont "fight" off infection...so they shouldnt elevate normally under any circumstances..
However, Im not a doctor, and I dont want you to count on that answer..its something to talk to your Neuro about. Wish I had more answers, but I only know what they are, not necessarily how they are affected.
Here's what I found. What I highlighted in bold, I find odd.
The prevalence of circulating antinuclear antibodies (ANA) was studied in a group of 147 patients with multiple sclerosis (MS). Also analyzed was the evolution of ANA over time in those patients for whom the first analysis was positive. ANA titers > or = 1/50 were considered positive. Twenty-two of the MS patients (15%) were positive for ANA upon the first analysis. In a control group of patients with other non-autoimmune neurological diseases the prevalence of ANA positivity was 6.1%. ANA titers became normal in 94.7% of the MS patients over a mean maximum period of 22.5 +/- 19.2 months. We known of no other study of the evolution of ANA titers in MS patients. Because ANA fluctuates in MS, the titers of other circulating autoantibodies should be interpreted cautiously both when discussing etiopathogenetic hypotheses and when diagnosing associated diseases. The diagnostic usefulness of ANA determination in MS is low.
I'm waiting for these results by mail. Every time I get any test, I ask for the results to be mailed to me. My MS specialist ordered a whole bunch of blood work. I'm interested in the ANA as well as the CPK. The CPK tells the doctors if something is going on (or happened) with the brain, heart, and muscle tissue.
Thanks for your responses Guys,
Nuthatch, your research is very interesting! I'm curious in this matter as I have just been given my first blood tests in over two years and there were a couple of abnormalities. I really believe I have been mismanaged by my earlier dr who wouldn't order blood tests. The new lovely dr I go to has done extensive tests.My blood glucose was 2 and this freaked her out as it was done 3pm on a typical working day where I had eaten and done all my usual activities. I have since had a fasting glucose which was 2.8. She seemed happier with that result. My folate level was low. I have started on supplements. The ANA result was worryingly high at 1:640. The dr states that at this level tissue damage can occur. She just doesn't know what tissue. It is a case of autoimmune activity somewhere. Finding the where is the issue. She is sending me to a physician. It will take a long time to get in to see him. I just don't want to waste time waiting when I could be healing.
With regards to ANA fluctuations, I wonder if they rise up with flares and lower when people are well. Nuthatches study didn't persue this train of thought. Just wondering if this may even be the case for flares in all sorts of autoimmune diseases.
Annie, I wonder the same about the flares. To be honest, it's a little confusing to me.
It seems that you might have hypoglycemia. Did your doctor suggest that? During the day, we shouldn't get that low. I'm hypoglycemic, and even though my doctor told me to eliminate ALL sugars, I disagree and so do many many other doctors. It's best to eat 5-6 small meals a day, but it's not always that easy. I don't find myself that hungry.
I understand all too well about waiting and waiting, and wanting to heal. If you haven't made your appt yet with the physician, when you do call, tell the secretary to put you on the cancellation list, so if someone cancels, you can be called in sooner. When another doctor tells me to see another, I'm pushy. I tell the secretary that my doctor wants me in ASAP because something was found wrong in my blood work, or whatever the case may be. Usually it works.
Let us know what happened, k?
I will bully a fast appointment. I deserve it!! LOL.
Yes, I'm sure I have hypoglycemia. Sometimes I shake with hunger and am ravenous. Often I am lightheaded. I will have to watch my diet and go for low GI foods. I wonder if hypoglycemia and the ANA are linked? Still confused.
Just found this -
...... antinuclear antibodies may be negative during periods of low disease activity or remission. Because titers of these antibodies tend to rise during flares of disease activity, specific antibody tests as well as ANA titers can be used to measure the response to treatment and disease prognosis".
Very interesting. It probably pays to have all tests done when you are unwell, don't you think? My MRI was given when I felt great! 5 months after my initial dr's visit. I wonder what an MRI today would find? Mind you, the research I am doing suggests with the pattern and level SLE could be on the cards. Will have to research that now.