I don't know whether this will help or cause more confusion, but here goes:
I've been on Copaxone for two and a half years, with no relapses since a month after i started ... site reactions for me are invisible but involve burning whie the fluid is absorbing (about 20 minutes every night.)
I've had two atypical IPIR reactions, both during an injection but neither one followed the IPIR descriptions and doctors said the timing was coincidental. And so I have continued, and have no new lesions since beginning.
I have never had symptoms that required steroid treatments.
My doctor recommended Copaxone because he knew I would not be compliant with a medication that threatened to take me out of the classroom once or twice a week. I know the interferons don't do that to everyone, but I wasn't willing to risk it. Copaxone causes none of those symptoms, and risks no liver damage, etc. So it was an easy sell, despite the nightly schedule and the 20 minute burn ...a constant reminder of MS itself.
I'll continue until I retire in a few years, and then will probably stop. It is a medically-lonely treatment, and I thank God I have my husband's support. Doctors don't ever discuss it, don't ever ask how it's going ... they just prescribe it and send you on your merry way, or tell you to talk to the telephone nurses connected to the drug manufacturer ... they are pleasant but very far away, and it feels so impersonal to talk to a stranger about your concerns.
I resent that the pharmaceuticals haven't found a way to formulate the solution without the after-burn ... no big deal, they may think ... it stops ... but it's unnecessary in today's world of analgesics ...
And as for the promise of the oral meds ... they haven't been around enough yet to prove whether they are side-effect free or not ... and I'm not risking my digestive system, which so far is working fine.
As one poster here said when I was beginning, don't agonize over choice - we're all individuals, we all react differently, and you can always stop and try a different one after a while ...
If they would make it a more humane treatment, like the care that Tysabri patients receive every month from dedicated nurses, I might continue it. But right now, my feeling is that it's my best hedge against progression before retirement, but once I'm free to, I'm done with the treatments.
Wishing you well with whatever you choose.