A study published in The Lancet (medical journal) in 1998 showed that while the body temperature of the women who were studied was on average 0.4 F hotter than the men, their hands were 2.8 F colder. The study showed that this is partly due to hormones. The female hormone estrogen regulates the peripheral blood vessels; high levels of this hormone make them more sensitive to temperature.
Before you make a connection with intolerances due to MS, it may be in actuality a hormonal problem. For me it is MS and is most likely to occur when the temperatures drop below 52 F (11.11 C). Other MSers might find their own point of cold intolerance.
A woman’s temperature will also vary during a menstrual cycle as the estrogen levels rise and fall.
Cold hands and feet can occasionally be a sign of something more sinister — the blood flow in your body may be interrupted because a vein or artery in the leg has become furred up by fatty deposits, a condition known as peripheral arterial disease.
If you have MS and cold hands and feet, have your doctor check to see if your problem is MS or another cause. Stay strong!!