I have had Polymyositis for a year and a half , when after Prednisone and Methotrexate therapy it appeared to be in remission . I still was on Methotrexate and taken off Prednisone. I was so happy thinking I was in remission, but after about two weeks I started having muscle pain and weakness again .
Not wanting to believe that it was back I went to get a CPK and it was elevated, the next week I was worse another CPK and it was even higher and the pain and weakness was relentless . After another week I was in so much pain worse than when my CPK was 1900 .
So I had to go back on Prednisone . The DR. said the disease was flaring up and was put back on 10mgs of Prednisone and the injectable form on Methotrexate at a higher dose . I took almost three months to start feeling better , but Methotrexate was making me sick for three days after the injections so now I am going to be put on Prednisone and Cellcept .