I gained 20lbs on celexa! I had to go off!!! Everyone reacts different to these drugs. My doc asked me if i wanted to mentally feel better? Or gain a few pounds? Well the weight gain was making me depressed! I just quit smoking...... I also have very poor body image, depression, OCD, bipolar, eating disorder, and ADD!!! So, i recently have put on some weight.....and i am FREAKING OUT!!! To top all that off im on total bed rest (?til mid july) from some surgery that im not healing from! I worked out 6-7 days a week! My phyciatrist put me on Lamictal 3 months ago....im on Wellbutrin and Buspar as well. Lamictal takes 1-2 months to feel the effects. I feel a very SLIGHT difference. Not enough though. Good luck in finding the "right" drug that will help you. It's just trial and error.......