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Old 03-24-2007, 10:24 AM   #1
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Anyone taking Ipriflavone Plus for Osteoporosis?

My alternative doc gave me Ipriflavone and Boron to help with my
osteoporosis. Also gave me Vit K. He said he had a female doctor who did fantastic
on it. Don't see much on the boards about it and was just wondering
if anyone is taking this.
Jodianne

 
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Old 03-24-2007, 02:04 PM   #2
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Hi Jodianne welcome!!! Is Ipriflavone a phytoestrogen? If so I've been taking plant estrogen for a while, but not specifically for osteo. I also get it in the soy products I eat, but just recently read an article on it, warning people to not take it if you have breast lumps, or a breast malignancy. Have you ever heard that? My gyno wants me to include soy in my diet for estrogen deficiency, but he didn't say anything about it helping osteo.

Good luck with this I hope it works...

Last edited by DesertBloom; 03-24-2007 at 02:05 PM.

 
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Old 03-24-2007, 04:21 PM   #3
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

DesertBloom,
The way I understand it from reading info on the net, Ipriflavone Plus
is a non-hormonal, isoflavone derivative. It is an alternate to estrogen.
Are you sure this is the same thing you are taking?? Doesn't sound like
it. Or did I misunderstand and it is not Ipriflavone that you are taking?
Jodianne

 
Old 03-25-2007, 09:15 AM   #4
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

The "2002 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada" issued by the "Scientific Advisory Council of the Osteoporosis Society of Canada" included an examination of the evidence regarding ipriflavone. It concluded that:
(a) Ipriflavone (200 mg, 3 times daily) is efficacious in maintaining BMD in the spine in postmenopausal women; and
(b) Ipriflavone is not efficacious in preventing fractures in postmenopausal women with osteoporosis.

The report also stated that patients taking ipriflavone should be monitored closely, since, in one study, ipriflavone use was associated with significant lymphopenia in 29 of 237 treated women.

Since 2002, there was another study (PubMed ID 15852487) which found that although ipriflavone does prevent bone loss, it does not not restore bone density which has been lost.

So it would seem that, for women, ipriflavone is a way to prevent bone loss, but if you already have osteoporosis, ipriflavone will not be effective in restoring the BMD which has been lost, and will not be effective in reducing the fracture rate.

I think everyone on this board with osteoporosis wants to restore our lost BMD, and not just stay where we are now. It would seem probable that something more effective than ipriflavone is needed for that.

Last edited by PikaB; 03-25-2007 at 09:22 AM.

 
Old 03-25-2007, 03:58 PM   #5
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Hi Jodianne: What I'm taking has Isoflavones in it, so that's why I asked the question about Ipraflavones, but maybe didn't word it very well. OTC phytoestrogens have Isoflavones in it and so does soy beans.

Pika thanks for the study on this I'll definitely read it, but I'm still not sure if I'm taking Ipraflavones but I suppose if it's a derivative of Isoflavones then it's in what I'm taking, or am I wrong?? Thought you might know since you know about soy products. I still can't find Natto anywhere near me

 
Old 03-25-2007, 04:50 PM   #6
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

PikaB
Thanks for your reply. This gets so confusing. Seems there are different
reports about this. I have a report from my alt doc from the 90's that states
Ostivone is ipriflavone (7-isopropoxy isoflavone) and that many studies show
that Ostivone, when taken in conjunction with calcium supplement increases bone mineral density significantly. The range of increase substantiated in both pre-clinical and well controlled clinical trials is between 3 and 9% in as short as 3 to 9 months. The daily intake was 600 mg per day in most studies.
And it goes on to state other benefits.
I guess I need to do more research for more updated information on this.
Thanks again for your input.
Jodianne

 
Old 03-25-2007, 05:00 PM   #7
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

DesertBloom
Thanks for your reply. I am going to copy this exactly as it is on the report
that the alt doc gave me.
The primary ingredient in Ostivone is ipriflavone (7-isopropoxy isoflavone) a naturally occuring substance now synthesized for nutritional use from the newly identified class of compounds known as isoflavones. Isoflavones belong to a group of compoounds known as bioflavonoids which are found in the plant kingdom. Isoflavones are also known as "phytoestrogens" due to their ability to mimic the hormone without the risks or side effects such as stimulating breast or uterine tissue growth.

So I guess this means they are all in the same family but are synthetic.

The more I read, the more confused I get!!

Jodianne

 
Old 03-25-2007, 06:08 PM   #8
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Jodianne; that is almost exactly what my Dr told me. I have an almost non existent estrogen level so that is why he wants me to include phytoestrogens, which are plant estrogens. Hopefully this will be cleared up soon, since I do have 1 breast lump, that I'm having an additional US and Spot views on. What I don't understand is how much safer is plant estrogens as opposed to rx estrogen.

Thanks for the reply...

 
Old 03-25-2007, 07:41 PM   #9
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

DesertBloom,
Ipriflavone falls into the large group of Isoflavonoids. Ipriflavone as used today as a bone building agent is a synthetic isoflavone derivative. It's best to read the article and maybe you
can understand it better. I'm still confused, but I think it is saying that Isoflavonoids are estrogen, but Ipriflavone is a synthetic. It mimics estrogen.
Somewhere I also read that Ipriflavone is a non-hormonal Isoflavone derivative. If you read the article, there is a sentence "Thus it has not been
reported to have the deleterious side-effects on breast and uterine tissue of estrogen therapy. Now that is the Ipriflavone, I don't know exactly what
you are taking, but I don't think your doc would give you something if
you already have a breast lump. I need to clarify this more w/ my doc too
since I have already had to breast biopsies in the last 10 years. I think I
just took it that Ipriflavone would not affect the breasts because it is
synthetic. But, who knows for sure.

I did read one thing though, that it can lower your white blood count
and you lymphocytes, not too thrilled to hear about that. You would have
to be chkd for that if you take it. I have the Ipriflavone here, but have
not started it yet. My reg doc (not alt) thinks I should try the Forteo,
that's shots that you give yourself every day. I can't take Fosamax or
Boniva because of stomach problems, don't want to take Evista because
that is estrogen and side effect is blood clots, so she mentioned the Forteo.
There's a message board on here in regard to Forteo.

So, let me know what you find out. I am thoroughly confused now!!!
Jodianne

Last edited by moderator2; 03-25-2007 at 07:44 PM. Reason: do not post commercial websites for any reason

 
Old 03-26-2007, 09:27 AM   #10
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Hi Jodianne: You mentioned Forteo in your last post, have you decided to take that since you can't take bisphosphonates (fosamax, actonel, boniva) or evista? I've been taking Forteo for 12 months now without any side effects. I and my Dr believe it's working well and there are a lot of other posters here that are on it or are just finishing it. If you get a chance try and read all the threads on Forteo, there's a lot of info there, plus they go way back on the board.

I'm still confused about the Ipriflavone question, but here goes again. I'm taking Isoflavones in tablet form and in soy products, so *is* ipriflavone in that since it is a derivative?

Good luck deciding what to take for the osteo

 
Old 03-26-2007, 05:27 PM   #11
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Hi Desert,
Yes, I have read the messages on Forteo and that I am still considering too.
I will probably try the Ipriflavone Plus first. I'm not sure I can take it because
of my stomach problems and if I can't then Forteo will have to be my resource.
I still can't answer your question. It sounds like the Isoflavones mimic
"phytoestrogens" but are non-hormonal and don't have the effect on the
breasts like estrogen would. I'm convinced Ipriflavone is not one that will
affect the breasts, it's synthetic. But, I can't say for sure Isoflavone
is the same.
Did you read about Ipriflavone on the Better Bones, Better Body site??
That's about all I have to go by too, so if you read that maybe that will
answer your question and clear it up for you.
Also ask your doctor if Isoflavones work like the real estrogen in regard to
affecting the breasts. I don't think they do, I think they are synthetic too
but not really sure.
Jodianne

 
Old 03-27-2007, 05:24 PM   #12
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

DesertBloom,
Just to add to the above, I found this explanation on the internet. Maybe
this will explain your question. Ipriflavone is a synthetic isoflavone. Isoflavones are the healthful component found in soy. Isoflavones are known as phytoestrogens because they affect the body similarly to estrogen. Ipriflavone was invented by scientists in 1969 to be a synthetic form of phytoestrogen with all of its good bone stimulating properties, but without other unwanted estrogen activity elsewhere in the body.
Jodianne

 
Old 03-27-2007, 07:41 PM   #13
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Re: Anyone taking Ipriflavone Plus for Osteoporosis?

Hi Jodianne: Thanks for the info... What you posted is what I've already read, but maybe it's a mute point now since I don't know if I will continue with it and the soy products, because I haven't made up my mind. Unfortunately I have other conflicting factors that may preclude this type of supplement and soy food products, but I still haven't made a definitve decision yet.

Good Luck to you on Ipriflavone if you decide to take it.

 
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