Re: strength of methadone??????????
When I swithed my docs use a 5:1 conversion,After a year on meth at 120mgs per day I went to 600mgs of Kadian, Kadian was dropped by my ins, plan and I went to generic MSC 200mgs TID and after a year on morphine I swithced back to the same 120 mgs of meth where I stayed for another year and a half.
You won't see a 5:1 conversion on anything but the most recent articles that suugest Meth has been underestimated for years and the equianelgesic tables are only acurate for single dose conversion. They do not take into acount the half life and build up of meth for the first 5 days.
Good luck, Dave
This is the conversion Dr Brookoff uses but you have to remeber, these are just guides to get you into the ballpark, they are safe so you won't OD and close enough to prevent withdrawal. But there is no absolute, you would likely still need adjutments unless you able to flip flop back and forth from one to the other.
Table 1. Equianalgesic
Doses of Opioid
Dose oral (mg)
This is the Unniversity of washingtons talarian index
Table 11. Dose equivalent for opioid analgesics for opioid-naive children and adults <50 KG BODY WEIGHT  Approximate equianalgesic dose
(MS Contin,Oramorph) =90-120 mg q 12 h
Hydromorphone (Dilaudid) =7.5 mg q 3-4 h
Levorphanol(Levo-Dromoran) =4 mg q 6-8 h
Meperidine(Demerol) = 300 mg q 2-3 h
Methadone(Dolophine, other) =20 mg q 6-8 h
Personally I think If you usd a 1:1 conversion on a partient using 600 mgs of morphine, and went to 600 mgs of methadone you would kill them in on the
There just isn't an absolute answer, There is one more I'll be back to show.
Good luck, Dave
The chart below indicates the
Daily Oral Morphine Dose Equivalents
followed by the
Conversion Ratio of Oral Morphine to Oral Methadone
<100 mg - 3:1 (i.e., 3 mg morphine:1 mg methadone)
101-300 mg - 5:1
301-600 mg - 10:1
601-800 mg - 12:1
801-1000 mg - 15:1
>1001 mg - 20:1
Due to incomplete cross-tolerance, it is recommended that the initial dose is 50-75% of the equianalgesic dose.
Last edited by Shoreline; 10-18-2004 at 11:11 AM.