Headache is one of the side effects of Opana. Can you take a little caffeine? I had some dental work done recently and was prescribed something similar and got a nasty headache. Because I get migraine headaches, I've tried all kinds of things to kill headache pain. For me, a little caffeine can do the trick. I keep a bottle of generic NoDoz, 200mg caffeine tablets. I break one in half and sometimes use it. If your condition allows you to have caffeine (no heart problems...) give it a try.