Originally Posted by schao
My question is..how much stronger is the oxycodone SA 10/325 vs. the Oxycontin 30 mg twice a day?
The short acting Oxycodone is packaged with Tylenol to increase it's pain fighting power. When you take a short acting med, it's immediately released and your blood plasma level (BPL) spikes. Then, the the BPL almost immediately declines....If you were to graph it, it would look like a "7" face down.....A spike in BPL that goes straight up and then declines on an angled line.
When you take the med again, the same thing happens. SA meds work great in the short run, but really aren't meant to be taken continuously throughout the day over the long run. This is what is known as the "ups and downs" of taking SA meds. Your Doc put you on a LA med to prevent this from happening.
Conversely, LA meds keep your BPL more stabilized. In fact, Purdue Pharma publishes in their white prescribing paper that 10mg of OC taken every 12 hours results in a higher BPL than 10mg of Oxycodone taken every 12 hours. Same qty of Oxycodone, but the OC results in higher BPL because it's consistent, releasing approximately 5mg of Oxy every 6 hours.
You'll probably find that the less up & downs not only helps with the consistent pain fighting, but also makes you feel better in general. Ups & downs can cause mini WDs in between doses. If needed, you could always add some OTC Tylenol if you find the OC doesn't work quite as well. However, you certainly didn't need all the Tylenol (6 x 325) day in and day out. Even though you were below the warning threshold, no one really knows the effects of taking Tylenol in heavy doses on a regular basis. There are many pain fighting alternatives out there and your Doc did a good job of switching you to one of them.
Hope this helps and best of luck to you.