THIS IS FOR INFORMATION PURPOSES ONLY. I AM NOT A DOCTOR, NOR DO I PLAY ONE ON T.V. I HAVE SEEN DOCTORS IN REAL LIFE, AND WILL SEE ONE TOMORROW. THESE ELABORATE CALCULATIONS ARE A RESULT OF MY UNDIAGNOSED OCD. I ACTUALLY DO NOT EVEN TAKE THE DRUG......YET.
~ Opana ER Interactions with Alcohol ~
8 ounces of a beer at 4% alcohol can double the Plasma concentration (Cmax)of Opana, which is the equivalent of raising a 10mg dose to 20mg, or raising a 30mg dose to 60mg.
2 ounces (big shot) of 80 proof alcohol can increase the Plasma Concentration (Cmax) of Opana ER by 70%, which is the equivalent of raising a 10mg dose to 17mg, or raising a 30mg dose to 51mg.
8 ounces (4 Shots) of 80 proof alcohol can increase the Plasma Concentration (Cmax) of Opana ER by 260%, which is the equivalent of raising a 10mg dose to 36mg, or raising a 30mg dose to 108mg.
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Information from Opana ER FDA Label/Opana ER Insert.
"Oxymorphone may be expected to have additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression because respiratory depression, hypotension, and profound sedation or coma may result. An in vivo study examined the effect of alcohol (40%, 20%, 4% and 0%) on the bioavailability of a single dose of 40 mg of OPANA ER in healthy, fasted volunteers. The results showed that the oxymorphone mean AUC was 13% higher (not statistically significant) after co-administration of 240 mL of 40% alcohol. The AUC was essentially unaffected in subjects following the co-administration of OPANA ER and ethanol (240 mL of 20% or 4% ethanol).
There was a highly variable effect on Cmax with concomitant administration of alcohol and OPANA ER. The change in Cmax ranged from a decrease of 50% to an increase of 270% across all conditions studied. Following concomitant administration of 240 mL of 40% ethanol the Cmax increased on average by 70%, and up to 270% in individual subjects. Following the concomitant administration of 240mL of 20% ethanol the Cmax increased on average by 31% and up to 260% in individual subjects. Following the concomitant administration of 240 mL of 4 % ethanol, the Cmax increased by 7% on average and as much as 110% for individual subjects."
