I've been on Requip since the day it was available. I've had PD 15 yrs,and I'm now 61. I take 4mg four times a day. I'm convinced it's the reason I can get by with only 1/2 tab of Sinemet 3 times a daY. Whenever I see a new Dr, they are amazed at how well I'm doing and how litttle Sinemet I take after so many years. I've tried all the new drugs as they came out--Azilect, Neupro patch etc but always came back to Requip. If I take it without eating I will yawn and yawn, I think it makes me gain weight , and I do love to play the slots! These are things i CAN live with-some days you wouldn't know I havce PD, but I do have bad days like everyone. My DR said he doesn't have any patients on as high a dose, but it works for me.