I take a combination of requip and seroquel. I am also allowed to take valium as needed. I am down to being up once a nihjt to hit the bathroom. I was up most of the night a one time. You picked a toughy cas all these drugs effect people differently. The same pills don't work on my wife. It is like most of these posters say, it is kind of trial and error. I am a great believer in 2 nd. opions though,that helped me find my mix.