Originally Posted by midwest1
Cytomel suppresses TSH.
Thanks, Midwest. I guess, then, that the pituitary responds to levels of the active hormone, T3, rather than T4? That would make sense. So, if you're artificially raising T3 with Cytomel, then TSH would decrease, as would T4.
FWIW, my labs at diagnosis (8/07) were:
TSH: 2.104 (.350-5.50)
FT4: 1.04 (.61-1.76) 37% of range
TPO AB 379 (0-34)
TG AB 59 (0-40)
FT3 test was not run, and I didn't know to ask for it.
Because of the antibodies, and because I was highly symptomatic, and because of a strong family history of thyroid issues, I was started on 25mcg Synthroid.
Symptoms largely resolved and I felt pretty good for about 9 months. Then symptoms returned with a vengeance and by the time I got to my endo, labs (9/08) were:
TSH: 1.71 (.40-4.50)
FT4: 1.04 (.8-1.8)
FT3: 326 (230-420)
TPO AB: 437 (< 35)
TG AB: 2694 (< 20)
My endo thought everything was fine, but I insisted on an increase to 50mcg Synthroid.
I continued to feel wretched. Labs drawn six months later (3/09) were:
TSH: 1.33 (.40-4.50)
FT4: 1.15 (.8-1.8)
FT3: 292 (230-420)
TPO AB: 566 (< 35)
TG AB: > 3000 (< 20)
At this point, I could barely function. The endo said I was fine; he wasn't even sure, he said, that I had Hashimoto's.
I found a new doctor the following month who added some Cytomel, and also uncovered my serious deficiences in Iron, Ferritin, B12, and D. I went on prescription-strength Iron for 6 months and continue to supplement B12 and D. For some reason, I have a really hard time keeping my Vitamin D at a healthy level. I'm currently taking 7000 ius of D3 daily.
I saw my current doctor last week (lab results in my original post), and she did bump up the Synthroid slightly (to 62.5 mcg).
Since going on the Cytomel, I've been improving. (Except for the 8-month period I was on sustained-release Cytomel; that raised my T3 levels, but didn't help at all with symptoms. There must have been something in the compounding that interfered somehow.)
Anyway, as you can see, my TSH has never been all that high, and my FT4 has never been even at mid-range, so I guess that's what got me thinking about the pituitary.
Thanks so much for all your help. If you have any suggestions/analysis based on the above history, I'd really welcome your thoughts.
I don't know what kind of shape I'd be in without the people on this board and their excellent advice . .In fact, it was Javelina who suggested that the compounded Cytomel might have been causing problems. And it surely was!! As soon as I went back on the "straight" multi-dose Cytomel, I began feeling better immediately. Truly a lifesaver!!