This is no joke. I had twitching in my legs, esp at nite, and after experimenting with stopping certain overthecounter and prescribed drugs, I discovered that it went away when I didnt use ranitidine. when i would use it for more than 2 days for heartburn, then the twitching came back. Everyone reacts differently to drugs, and perhaps you all can try what i did and find the culprit. It could be something that seems so harmless but just tips that delicate balance that our bodies need...Patty