Hi Confused. Yes, there are other things that can look like herpes, such as jock itch, a heat rash, razor burn, allergic reaction, the list goes on and on. I know that HSV resides in the nerve ganglions (sp?), and that outbreaks can occur anywhere in the area covered by boxer shorts. However, I am not positive that the first outbreak could occur anywhere, or if it would occur where the virus initially entered the body. There is a great Herpes board on here, why don't you repost on there? I'm sure you would get a definite answer very quickly.