If it's not under control with that many meds. than maybe those meds. aren't right for you. The more meds., the more chance for lots of terrible side-effects (trust me). Altace was horrible when I took it, Toprol was really bad, Atenolol is causing me all kinds of trouble at times, Lotrel works well (sometimes too well). I wish I could just take one med. My B/P has been consistently around 114/64 & Lotrel & Atenolol is too much. My system can't take 100 MGS of Atenolol & 5/20 of Lotrel. My B/P might be really low, but what about quality of life??? I'm 33, thin 5 '11 151, drink no alcohol, & my only vice is smoking. I didn't smoke for an entire afternoon & my b/p was 107/60.