I also have RA that lives mostly in my wrists and hands. I had pain and swelling and a solid mass of flesh over the tops of my hands so that it looked as tho' I had no knuckles at all. My Dr. put me on Methotrexate, Embrel and Mobic and the swelling went away but most of the pain stayed. I can live with that as it only really bothers me on stinky rainy cool days. Who needs a weather man? I had another Dr. prescribe percocet for another problem and found that I have a life again. I can crochet, knit, latch hook, sew, I can even use a knife and fork again. The percocet is a low dose and I am careful with it. My RA is also in my feet, knees (OA) there, hips and shoulders, and I'm beginning to suspect my spine may be involved also. I just spent 9 days in the hospital and the only place they could find to put an IV was the base of my wrists, yes, I had two of them, and when they blasted, they moved them to the backs of my hands. I'm still trying to get over those. By the way I'm female on the other side of young, but I hurt just like you guys do. Good luck to you all.