Technically there are no drug interactions on the books meaning neither has been documented to interfere with the effectiveness of the other, but for every person it is different. Also since accutane causes depression in some people it could seem to make the antidepressant less effective, although indirectly. For me I believe that both are working, although my skin has been slow to clear up and is very red with scars. My doctors dont think the antidepressant will interfere with skin clearing though, if any drug was going to influence the other, it would be the accutane influencing your anxiety, not the other way around, so I would definitely try something for relief of your anxiety symptoms without too much fear of additional skin problems. That being said, Id ask a doctor, too.