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Old 06-01-2006, 06:21 AM   #6
Sharon76
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Re: Crohn's and azathioprine

I got it wrong, i'm actually on 4000mg of pentasa daily, which is the higher dose i think.

Also i have just found some interesting info on crohn's.

Apparently there is a bacteria that is present in cows called MAP, this has the same symptoms in cows as people with regards to crohn's. A study has been done with lots of research and this bacteria can be passed along to humans by infected milk from cows. Apparently the level that they pasturise milk at is not high enough to kill this bug. And it can also be passed along from meat by cows. The disease in cows is know as johnes disease. But the worrying thing is this MAP bug is also present in the environment!!! It can also be carried in water.

Whilst doing this research they also discovered that alot of people with crohns had this MAp bug in their system.


But saying this the researchers cannot say that this is the sole cause of crohns in humans, there are many other factors which can cause it. At the moment scientists are working on a vaccine for crohns and hopefully get rid of this bug which is contributing to crohns.



I found this interesting.
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Old 06-01-2006, 07:40 AM   #7
Angela22F
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Re: Crohn's and azathioprine

I read something similar while researching yesterday. It is very interesting indeed. Makes ya wonder.

Alot of people with Crohn's are "lactose" intolerant... is it possible its this MAP bug and not the lactose? Just an idea. I'd like to know what they find in their further studies.

How are you feeling today? (And I figured a bump would be nice Hoping someone still has some info on the azathioprine... Have you made any further decision?)

Angela
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Old 06-02-2006, 12:31 AM   #8
mfife31
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Re: Crohn's and azathioprine

Well my son has autoimmune hepatitis and has been on 6-mp since dec '05.What he is on(6-mp), is what azathiprine(or Imuran)(Its the brand name of aza)turns into once you take it. From what I have learned is that they check your metabolites for this drug before you take it (TPMP level)to see how low of a dose to start it,Then his levels are checked once a month. Actually his were way too high for a couple of months and had to lower his dose.This drug helps to put you on a lower dose of steroids(called also a steroid sparing drug).It does take a couple of months to begin to work effectively, that is why they usually start with steroids and the Imuran, then taper the steroids down.Hope that helps some! You may want to check out Prometheus labs website, It is the lab that tests the metabolite levels.
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Old 06-02-2006, 12:23 PM   #9
Sharon76
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Re: Crohn's and azathioprine

Hi Mfife

HAs your son had any bad side effects or problems since being on them?
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Old 06-02-2006, 11:57 PM   #10
mfife31
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Join Date: May 2006
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Re: Crohn's and azathioprine

Hi! Actually we havent really noticed any so far.The only time we did was when the metabolite of the drug got too high.. then his bilirubin went to 4.5 his platelets dropped slightly to 110. But as far as how he felt no. And once it was reduced , the blood labs went back to normal. Good luck to you!! I am a member of autoimmune hepatitis group and there is alot of info about the azathioprine. There are quite a few there who take it.
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