Ok I have been on Ortho Lo for 7 months, and I still have to take antibiotics, but when I first began taking it I had cystic acne on my cheeks for the first couple of months, which i've never had. It has gone away now but I do not know if the Lo has worked for me or not but I think it has improved my skin some. I am switching to Ortho Tri Cyclen tommorow hopefully since it is recommended for acne. I won't start it for a few weeks, but I will post about how it works for me.