I used Klaron for a couple of weeks and my acne just kept getting worde and worse. I didn't understand what was going on. I thought maybe it was my pills, turns out i am allergic to it. I've been off of it for 2 days and i can see a major difference!! So hopefully you won't have the same problem!! How long have you been using clinda and differin? I used it a while back and it completely cleared my skin except for around my time. But I ended up stopping the differin be/c of tanning, it was drying my skin out to much doing both. I never really had too much of a problem with acne (I didn't get a lot at one time). I get cysts. But I always did have at least one or two pimple on my face at all times, big painful ones (cysts). But the clinda and differin help alot like I said. Oh and the Klaron that I had was a lotion. I don't know if it comes in anything else. I never even heard about it until recently, when the derm gave it to me.