Hello. I have been taking Spironolactone for 5 years. When I was 22, my skin broke out really bad and my skin was always very oily. I was upset and searched the message boards for any solutions. I came across a post from a women who said that Spiro changed her life. I started it, and within a month my skin was no longer oily and everything cleared up. I experienced no side effects whatsoever. I heard that a lot of Derms are reluctant to prescribe this medication simply because it hasn't been used to treat acne for that long. It is normally used for high blood pressure. I did read an article in Allure magazine last month that was written by Katie Rodan (one of the women who invented Proactiv, and is also a derm herself) that she prescribes Spiro on a regular basis for people with hormonal acne. If I run out of the pills or miss a day, I notice my skin getting oily again. It's the strangest thing. I have been taking one 100mg tablet every day for fives years. I also read that Yasmin (the birth control) is made with Spiro, and this is why it helps with acne. I hope this gives some insight!