idk dude...i tried it myself on a cyst just the other day, and it didnt seem to do ****...it DID start to go down yesterday (i doubt it was because of the hydrocortisone) , but then unfortunately like the idiot i am, i popped it tonite, and it will probably swell again...i think OTC hydrocortisone is simply not strong enough, and doesnt pass through the epithelial cells -- hence the cortisol shots