Here is my experience all together. Be/c I really don't know what is going on. So I can't say if the doxy works or not. i am on my second pack of yasmin, day 27 of spiro, a little over a month on doxy, and have been taking predisone for about 2 months on and off. And all my face is doing is getting worse. A week after the derm appointment where I got the doxy and he also gave me klaron (which I think i am allergic too so he told me to stop all topicals) I broke out very bad. And it hasn't gotten any better. I have a derm appointment tomorrow and watch I will laugh so hard if he tells me it looks better be/c seriously it doesn't and the last time I went he said that and i went there with more breakouts then i ever had. So, I don't know if it's an inital breakout or what be/c one day it looks like hmmm it's going to start getting better then the next day I have have more breakouts. So I really can't tell you much about the doxy be/c to tell you the truth I don't think it's doing a thing for me. I do know that ALOT of people on here thing it's great! So I just don't know if maybe it's be/c of all the other things that I am taking or not. I just don't know what's going on at the moment. I do know that I get very sick when I take doxy. I have to eat something then take the pill about 30 mins after eatting. I think the first or second day taking it i throw it back up be/c i got so sick from it. Now if I don't eat enough then I will get very sick lay o the bathroom be/c it feels like im going to throw up but i try to push through it. I have been having a very hard time with all of this. I wish you the best of luck!