I had a very rough time with zetia, though I didn't have my liver functions tested during that time. Another supplement that is good for the liver is SAM-e. I had a gastro at a prestigious hospital say that he recommended it for patient who couldn't take other liver drugs when I told him I was taking it for arthritis but it had helped my liver tests come back to normal. It's expensive, but NatureMade brand is frequently on sale 2 for 1, so I buy it then.